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Potential Antiviral Options against SARS-CoV-2 Infection

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, 7028 Trondheim, Norway
Department of Medical Microbiology, St. Olavs Hospital, 7006 Trondheim, Norway
Department of Immunology and Transfusion Medicine, St. Olavs Hospital, 7006 Trondheim, Norway
Institute of Technology, University of Tartu, 50090 Tartu, Estonia
Institute of Genomics Core Facility, University of Tartu, 51010 Tartu, Estonia
Author to whom correspondence should be addressed.
Viruses 2020, 12(6), 642;
Received: 14 May 2020 / Revised: 9 June 2020 / Accepted: 11 June 2020 / Published: 13 June 2020
(This article belongs to the Special Issue Antiviral Drug Combinations)
As of June 2020, the number of people infected with severe acute respiratory coronavirus 2 (SARS-CoV-2) continues to skyrocket, with more than 6.7 million cases worldwide. Both the World Health Organization (WHO) and United Nations (UN) has highlighted the need for better control of SARS-CoV-2 infections. However, developing novel virus-specific vaccines, monoclonal antibodies and antiviral drugs against SARS-CoV-2 can be time-consuming and costly. Convalescent sera and safe-in-man broad-spectrum antivirals (BSAAs) are readily available treatment options. Here, we developed a neutralization assay using SARS-CoV-2 strain and Vero-E6 cells. We identified the most potent sera from recovered patients for the treatment of SARS-CoV-2-infected patients. We also screened 136 safe-in-man broad-spectrum antivirals against the SARS-CoV-2 infection in Vero-E6 cells and identified nelfinavir, salinomycin, amodiaquine, obatoclax, emetine and homoharringtonine. We found that a combination of orally available virus-directed nelfinavir and host-directed amodiaquine exhibited the highest synergy. Finally, we developed a website to disseminate the knowledge on available and emerging treatments of COVID-19. View Full-Text
Keywords: antivirals; broad-spectrum antivirals; antiviral drug combinations antivirals; broad-spectrum antivirals; antiviral drug combinations
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MDPI and ACS Style

Ianevski, A.; Yao, R.; Fenstad, M.H.; Biza, S.; Zusinaite, E.; Reisberg, T.; Lysvand, H.; Løseth, K.; Landsem, V.M.; Malmring, J.F.; Oksenych, V.; Erlandsen, S.E.; Aas, P.A.; Hagen, L.; Pettersen, C.H.; Tenson, T.; Afset, J.E.; Nordbø, S.A.; Bjørås, M.; Kainov, D.E. Potential Antiviral Options against SARS-CoV-2 Infection. Viruses 2020, 12, 642.

AMA Style

Ianevski A, Yao R, Fenstad MH, Biza S, Zusinaite E, Reisberg T, Lysvand H, Løseth K, Landsem VM, Malmring JF, Oksenych V, Erlandsen SE, Aas PA, Hagen L, Pettersen CH, Tenson T, Afset JE, Nordbø SA, Bjørås M, Kainov DE. Potential Antiviral Options against SARS-CoV-2 Infection. Viruses. 2020; 12(6):642.

Chicago/Turabian Style

Ianevski, Aleksandr, Rouan Yao, Mona Høysæter Fenstad, Svetlana Biza, Eva Zusinaite, Tuuli Reisberg, Hilde Lysvand, Kirsti Løseth, Veslemøy Malm Landsem, Janne Fossum Malmring, Valentyn Oksenych, Sten Even Erlandsen, Per Arne Aas, Lars Hagen, Caroline H. Pettersen, Tanel Tenson, Jan Egil Afset, Svein Arne Nordbø, Magnar Bjørås, and Denis E. Kainov. 2020. "Potential Antiviral Options against SARS-CoV-2 Infection" Viruses 12, no. 6: 642.

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