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Open AccessArticle

Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling

1
The Pirbright Institute, Pirbright, Surrey GU24 0NF, UK
2
Faculty of Health and Medical Sciences, School of Biosciences and Medicine, University of Surrey, Guildford, Surrey GU2 7XH, UK
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(5), 536; https://doi.org/10.3390/v12050536
Received: 10 April 2020 / Revised: 12 May 2020 / Accepted: 12 May 2020 / Published: 14 May 2020
Viruses must hijack cellular translation machinery to express viral genes. In many cases, this is impeded by cellular stress responses. These stress responses result in the global inhibition of translation and the storage of stalled mRNAs, into RNA-protein aggregates called stress granules. This results in the translational silencing of the majority of mRNAs excluding those beneficial for the cell to resolve the specific stress. For example, the expression of antiviral factors is maintained during viral infection. Here we investigated stress granule regulation by Gammacoronavirus infectious bronchitis virus (IBV), which causes the economically important poultry disease, infectious bronchitis. Interestingly, we found that IBV is able to inhibit multiple cellular stress granule signaling pathways, whilst at the same time, IBV replication also results in the induction of seemingly canonical stress granules in a proportion of infected cells. Moreover, IBV infection uncouples translational repression and stress granule formation and both processes are independent of eIF2α phosphorylation. These results provide novel insights into how IBV modulates cellular translation and antiviral stress signaling. View Full-Text
Keywords: infectious bronchitis virus; IBV; stress granule; SG; eIF2α; host shut-off; translation inhibition infectious bronchitis virus; IBV; stress granule; SG; eIF2α; host shut-off; translation inhibition
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MDPI and ACS Style

Brownsword, M.J.; Doyle, N.; Brocard, M.; Locker, N.; Maier, H.J. Infectious Bronchitis Virus Regulates Cellular Stress Granule Signaling. Viruses 2020, 12, 536.

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