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Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection

Division of Gastroenterology and Hepatology, Department of Medicine, Nihon University School of Medicine, 30-1 Oyaguchi-kamicho, Itabashi-ku, Tokyo 173-8610, Japan
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Viruses 2020, 12(5), 533; https://doi.org/10.3390/v12050533
Received: 4 April 2020 / Revised: 9 May 2020 / Accepted: 10 May 2020 / Published: 12 May 2020
(This article belongs to the Section Animal Viruses)
Hepatitis A virus (HAV) infection is one of the major causes of acute hepatitis, and this infection occasionally causes acute liver failure. HAV infection is associated with HAV-contaminated food and water as well as sexual transmission among men who have sex with men. Although an HAV vaccine has been developed, outbreaks of hepatitis A and life-threatening severe HAV infections are still observed worldwide. Therefore, an improved HAV vaccine and anti-HAV drugs for severe hepatitis A should be developed. Here, we reviewed cell culture systems for HAV infection, and other issues. This review may help with improving the HAV vaccine and developing anti-HAV drugs. View Full-Text
Keywords: Anti-HAV; drug screening; HAV; Huh7; IRES; PLC/PRF/5; subgenomic replicon; 5′ UTR; vaccine Anti-HAV; drug screening; HAV; Huh7; IRES; PLC/PRF/5; subgenomic replicon; 5′ UTR; vaccine
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Kanda, T.; Sasaki, R.; Masuzaki, R.; Matsumoto, N.; Ogawa, M.; Moriyama, M. Cell Culture Systems and Drug Targets for Hepatitis A Virus Infection. Viruses 2020, 12, 533.

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