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Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection
Open AccessReview

Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death

Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia
Department of Molecular and Translational Sciences, Monash University, Clayton, VIC 3168, Australia
Master de Biologie, École Normale Supérieure de Lyon, Université Claude Bernard Lyon I, Université de Lyon, 69007 Lyon, France
Author to whom correspondence should be addressed.
Viruses 2020, 12(4), 401;
Received: 13 March 2020 / Revised: 1 April 2020 / Accepted: 1 April 2020 / Published: 4 April 2020
(This article belongs to the Special Issue Influenza A Virus: Host-Virus Relationship)
Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of significant crosstalk between cell death and inflammatory pathways and a greater understanding of their role in host defence and disease may facilitate the design of new treatments for IAV infection. View Full-Text
Keywords: Influenza A virus; cell death; inflammation; pathogenesis Influenza A virus; cell death; inflammation; pathogenesis
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Laghlali, G.; Lawlor, K.E.; Tate, M.D. Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death. Viruses 2020, 12, 401.

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