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Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection

State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China
Author to whom correspondence should be addressed.
Viruses 2020, 12(4), 376;
Received: 28 February 2020 / Revised: 19 March 2020 / Accepted: 25 March 2020 / Published: 29 March 2020
(This article belongs to the Special Issue Influenza A Virus: Host-Virus Relationship)
Influenza A viruses (IAVs) are highly contagious pathogens infecting human and numerous animals. The viruses cause millions of infection cases and thousands of deaths every year, thus making IAVs a continual threat to global health. Upon IAV infection, host innate immune system is triggered and activated to restrict virus replication and clear pathogens. Subsequently, host adaptive immunity is involved in specific virus clearance. On the other hand, to achieve a successful infection, IAVs also apply multiple strategies to avoid be detected and eliminated by the host immunity. In the current review, we present a general description on recent work regarding different host cells and molecules facilitating antiviral defenses against IAV infection and how IAVs antagonize host immune responses. View Full-Text
Keywords: influenza A virus; innate immunity; adaptive immunity influenza A virus; innate immunity; adaptive immunity
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Zhang, Y.; Xu, Z.; Cao, Y. Host–Virus Interaction: How Host Cells Defend against Influenza A Virus Infection. Viruses 2020, 12, 376.

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