Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins
by
Suhas Srinivasan 1
, Hongzhu Cui 2, Ziyang Gao 2, Ming Liu 2, Senbao Lu 2, Winnie Mkandawire 2, Oleksandr Narykov 3, Mo Sun 2 and Dmitry Korkin 1,2,3,*
Suhas Srinivasan 1, Hongzhu Cui 2, Ziyang Gao 2, Ming Liu 2, Senbao Lu 2, Winnie Mkandawire 2, Oleksandr Narykov 3, Mo Sun 2 and Dmitry Korkin 1,2,3,*
1
Data Science Program, Worcester Polytechnic Institute, Worcester, MA 01609, USA
2
Bioinformatics and Computational Biology Program, Worcester Polytechnic Institute, Worcester, MA 01609, USA
3
Computer Science Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(4), 360; https://doi.org/10.3390/v12040360
Received: 24 February 2020 / Revised: 15 March 2020 / Accepted: 20 March 2020 / Published: 25 March 2020
(This article belongs to the Special Issue Pathogenesis of Human and Animal Coronaviruses)
During its first two and a half months, the recently emerged 2019 novel coronavirus, SARS-CoV-2, has already infected over one-hundred thousand people worldwide and has taken more than four thousand lives. However, the swiftly spreading virus also caused an unprecedentedly rapid response from the research community facing the unknown health challenge of potentially enormous proportions. Unfortunately, the experimental research to understand the molecular mechanisms behind the viral infection and to design a vaccine or antivirals is costly and takes months to develop. To expedite the advancement of our knowledge, we leveraged data about the related coronaviruses that is readily available in public databases and integrated these data into a single computational pipeline. As a result, we provide comprehensive structural genomics and interactomics roadmaps of SARS-CoV-2 and use this information to infer the possible functional differences and similarities with the related SARS coronavirus. All data are made publicly available to the research community.
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Keywords:
2019 novel coronavirus; SARS-CoV-2; 2019-nCoV; COVID-19; structural genomics; interactome; protein-protein interactions
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MDPI and ACS Style
Srinivasan, S.; Cui, H.; Gao, Z.; Liu, M.; Lu, S.; Mkandawire, W.; Narykov, O.; Sun, M.; Korkin, D. Structural Genomics of SARS-CoV-2 Indicates Evolutionary Conserved Functional Regions of Viral Proteins. Viruses 2020, 12, 360.
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