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Review

Host Transcription Factors in Hepatitis B Virus RNA Synthesis

1
Alberta RNA Research and Training Institute, Department of Chemistry and Biochemistry, University of Lethbridge, 4401 University Dr. W., Lethbridge, AB T1K 3M4, Canada
2
Department of Microbiology, Immunology and Infectious Diseases, Cumming, School of Medicine, University of Calgary, 2500 University Dr. N.W., Calgary, AB T2N 1N4, Canada
3
Department of Medicine, Division of Gastroenterology and Hepatology, University of Calgary, 1403 29 St. N.W., Calgary, AB T2N 2T9, Canada
4
Discovery Lab, Faculty of Medicine & Dentistry, and the Li Ka Shing Institute of Virology, University of Alberta, 6-010 Katz Center for Health Research, Edmonton, AB T6G 2E1, Canada
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(2), 160; https://doi.org/10.3390/v12020160
Received: 5 December 2019 / Revised: 27 January 2020 / Accepted: 28 January 2020 / Published: 30 January 2020
(This article belongs to the Special Issue Hepatitis B Virus: From Diagnostics to Treatments)
The hepatitis B virus (HBV) chronically infects over 250 million people worldwide and is one of the leading causes of liver cancer and hepatocellular carcinoma. HBV persistence is due in part to the highly stable HBV minichromosome or HBV covalently closed circular DNA (cccDNA) that resides in the nucleus. As HBV replication requires the help of host transcription factors to replicate, focusing on host protein–HBV genome interactions may reveal insights into new drug targets against cccDNA. The structural details on such complexes, however, remain poorly defined. In this review, the current literature regarding host transcription factors’ interactions with HBV cccDNA is discussed. View Full-Text
Keywords: hepatitis B virus (HBV); viral replication; transcription factors; covalently closed circular DNA (cccDNA); host–viral interactions hepatitis B virus (HBV); viral replication; transcription factors; covalently closed circular DNA (cccDNA); host–viral interactions
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MDPI and ACS Style

Turton, K.L.; Meier-Stephenson, V.; Badmalia, M.D.; Coffin, C.S.; Patel, T.R. Host Transcription Factors in Hepatitis B Virus RNA Synthesis. Viruses 2020, 12, 160. https://doi.org/10.3390/v12020160

AMA Style

Turton KL, Meier-Stephenson V, Badmalia MD, Coffin CS, Patel TR. Host Transcription Factors in Hepatitis B Virus RNA Synthesis. Viruses. 2020; 12(2):160. https://doi.org/10.3390/v12020160

Chicago/Turabian Style

Turton, Kristi L., Vanessa Meier-Stephenson, Maulik D. Badmalia, Carla S. Coffin, and Trushar R. Patel 2020. "Host Transcription Factors in Hepatitis B Virus RNA Synthesis" Viruses 12, no. 2: 160. https://doi.org/10.3390/v12020160

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