Block-And-Lock: New Horizons for a Cure for HIV-1
Abstract
:1. Introduction
2. HIV-1 Latency
3. HIV-1 Transcription
Tat-Mediated HIV-1 Transcription
4. Latency Reversal Agents
5. Block-And-Lock
5.1. Tat
5.2. Facilitates Chromatin Transcription (FACT) Complex
5.3. mTOR Complex (mTORC)
5.4. Bromodomain-Containing Protein 4 (BRD4)
5.5. Heat Shock Protein 90 (HSP90)
6. Other Sterilizing/Functional Cure Strategies
6.1. RNA-Based Strategies
6.2. CRISPR/Cas Systems
7. Discussion
Funding
Conflicts of Interest
References
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Moranguinho, I.; Valente, S.T. Block-And-Lock: New Horizons for a Cure for HIV-1. Viruses 2020, 12, 1443. https://doi.org/10.3390/v12121443
Moranguinho I, Valente ST. Block-And-Lock: New Horizons for a Cure for HIV-1. Viruses. 2020; 12(12):1443. https://doi.org/10.3390/v12121443
Chicago/Turabian StyleMoranguinho, Ines, and Susana T. Valente. 2020. "Block-And-Lock: New Horizons for a Cure for HIV-1" Viruses 12, no. 12: 1443. https://doi.org/10.3390/v12121443
APA StyleMoranguinho, I., & Valente, S. T. (2020). Block-And-Lock: New Horizons for a Cure for HIV-1. Viruses, 12(12), 1443. https://doi.org/10.3390/v12121443