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Review

Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes

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Laboratorio de Ingeniería Genética y Biología Celular y Molecular—Área Virosis de Invertebrados, Departamento de Ciencia y Tecnología, Instituto de Microbiología Básica y Aplicada, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, B1876BXD Bernal, Buenos Aires, Argentina
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Laboratorio de Virus Emergentes, Departamento de Ciencia y Tecnología, Instituto de Microbiología Básica y Aplicada, Universidad Nacional de Quilmes, Roque Sáenz Peña 352, B1876BXD Bernal, Buenos Aires, Argentina
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Author to whom correspondence should be addressed.
Academic Editors: Manja Marz, Bashar Ibrahim, Franziska Hufsky, Ronald Dijkman, Alban Ramette and Jenna Kelly
Viruses 2020, 12(12), 1395; https://doi.org/10.3390/v12121395
Received: 24 October 2020 / Revised: 19 November 2020 / Accepted: 30 November 2020 / Published: 6 December 2020
(This article belongs to the Special Issue Virus Bioinformatics 2020)
Baculoviruses are a group of insect viruses with large circular dsDNA genomes exploited in numerous biotechnological applications, such as the biological control of agricultural pests, the expression of recombinant proteins or the gene delivery of therapeutic sequences in mammals, among others. Their genomes encode between 80 and 200 proteins, of which 38 are shared by all reported species. Thanks to multi-omic studies, there is remarkable information about the baculoviral proteome and the temporality in the virus gene expression. This allows some functional elements of the genome to be very well described, such as promoters and open reading frames. However, less information is available about the transcription termination signals and, consequently, there are still imprecisions about what are the limits of the transcriptional units present in the baculovirus genomes and how is the processing of the 3′ end of viral mRNA. Regarding to this, in this review we provide an update about the characteristics of DNA signals involved in this process and we contribute to their correct prediction through an exhaustive analysis that involves bibliography information, data mining, RNA structure and a comprehensive study of the core gene 3′ ends from 180 baculovirus genomes. View Full-Text
Keywords: Baculoviridae; mRNA; polyadenylation process; RNA structure; pattern-searching Baculoviridae; mRNA; polyadenylation process; RNA structure; pattern-searching
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MDPI and ACS Style

Peros, I.G.; Cerrudo, C.S.; Pilloff, M.G.; Belaich, M.N.; Lozano, M.E.; Ghiringhelli, P.D. Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes. Viruses 2020, 12, 1395. https://doi.org/10.3390/v12121395

AMA Style

Peros IG, Cerrudo CS, Pilloff MG, Belaich MN, Lozano ME, Ghiringhelli PD. Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes. Viruses. 2020; 12(12):1395. https://doi.org/10.3390/v12121395

Chicago/Turabian Style

Peros, Iván Gabriel, Carolina Susana Cerrudo, Marcela Gabriela Pilloff, Mariano Nicolás Belaich, Mario Enrique Lozano, and Pablo Daniel Ghiringhelli. 2020. "Advances in the Bioinformatics Knowledge of mRNA Polyadenylation in Baculovirus Genes" Viruses 12, no. 12: 1395. https://doi.org/10.3390/v12121395

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