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Article

Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico

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Laboratorio de Medicina de Conservación de la Sección de Estudios de Posgrado e Investigación, Escuela Superior Medicina, Instituto Politécnico Nacional, Plan de San Luis, Colonia Casco de Santo Tomas, Delegación Miguel Hidalgo, Ciudad de México 11340, Mexico
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Departamento de Zoología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Plan de Ayala, Colonia Casco de Santo Tomas, Miguel Hidalgo, Ciudad de México 11340, Mexico
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Laboratorio de Medicina Genómica, Departamento de Genética, Instituto Nacional de Rehabilitación-LGII, Calzada México Xochimilco No. 289, Colonia Arenal de Guadalupe, Ciudad de México 14389, Mexico
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Departamento de Microbiología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Plan de Ayala, Colonia Casco de Santo Tomas, Delegación Miguel Hidalgo, Ciudad de Mexico 11340, Mexico
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Coordinación de Planeación y Enlace Institucional, Delegación Veracruz Norte, Instituto Mexicano del Seguro Social, Lomas del Estadio S/N Xalapa, Veracruz 91090, Mexico
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Departamento de Bioquímica, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional, Plan de Ayala, Colonia Casco de Santo Tomas, Delegación Miguel Hidalgo, Ciudad de México 11340, Mexico
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Unidad de Investigación en Enfermedades Endocrinas, Hospital de Especialidades, Centro Médico, Nacional siglo XXI, Instituto Mexicano del Seguro Social, Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc, Ciudad de México 06720, Mexico
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Laboratorio de Biomedicina Molecular III (Virología) de la Sección de Estudios de Posgrado e Investigación, Escuela Nacional de Medicina y Homeopatía, Instituto Politécnico Nacional, Guillermo Massieu Helguera 239, La Escalera, Gustavo A. Madero, Ciudad de México 07320, Mexico
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Coordinación de Educación Médica Continua, Comité Normativo Nacional de Medicina General, Cuauhtémoc 330, Colonia Doctores, Delegación Cuauhtémoc CDMX 06720, Mexico
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(11), 1230; https://doi.org/10.3390/v12111230
Received: 31 August 2020 / Revised: 10 October 2020 / Accepted: 21 October 2020 / Published: 29 October 2020
(This article belongs to the Section Animal Viruses)
Dengue manifestations range from a mild form, dengue fever (DF), to more severe forms such as dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). The ability of the host to present one of these clinical forms could be related to polymorphisms located in genes of the Toll-like receptors (TLRs) which activate the pro-inflammatory response. Therefore, the genotyping of single nucleotide genetic polymorphisms (SNPs) in TLR3 (rs3775291 and rs6552950), TLR4 (rs2737190, rs10759932, rs4986790, rs4986791, rs11536865, and rs10983755), TLR7 (rs179008 and rs3853839), and TLR8 (rs3764880, rs5741883, rs4830805, and rs1548731) was carried out in non-genetically related DHF patients, DF patients, and general population (GP) subjects. The SNPs were analyzed by real-time PCR by genotyping assays from Applied Biosystems®. The codominance model showed that dengue patients had a lower probability of presenting the TLR4-rs2737190-G/G genotype (odds ratio (OR) (95% CI) = 0.34 (0.14–0.8), p = 0.038). Dengue patients showed a lower probability of presenting TLR4-rs11536865-G/C genotype (OR (95% CI) = 0.19 (0.05–0.73), p = 0.0092) and had a high probability of presenting the TACG haplotype, but lower probability of presenting the TGCG haplotype in the TLR4 compared to GP individuals (OR (95% CI) = 0.55 (0.35–0.86), p = 0.0084). In conclusion, the TLR4-rs2737190-G/G and TLR4-rs11536865-G/C genotypes and TGCG haplotype were associated with protection from dengue. View Full-Text
Keywords: toll-like receptor; dengue; gene polymorphisms; dengue fever; dengue hemorrhagic fever; human genetic susceptibility toll-like receptor; dengue; gene polymorphisms; dengue fever; dengue hemorrhagic fever; human genetic susceptibility
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MDPI and ACS Style

Posadas-Mondragón, A.; Aguilar-Faisal, J.L.; Zuñiga, G.; Magaña, J.J.; Santiago-Cruz, J.A.; Guillén-Salomón, E.; Alcántara-Farfán, V.; Arellano-Flores, M.L.; Salas-Benito, J.S.; Neri-Bazán, R.M.; Luna-Rojas, L.; Avila-Trejo, A.M.; Chávez-Negrete, A. Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico. Viruses 2020, 12, 1230. https://doi.org/10.3390/v12111230

AMA Style

Posadas-Mondragón A, Aguilar-Faisal JL, Zuñiga G, Magaña JJ, Santiago-Cruz JA, Guillén-Salomón E, Alcántara-Farfán V, Arellano-Flores ML, Salas-Benito JS, Neri-Bazán RM, Luna-Rojas L, Avila-Trejo AM, Chávez-Negrete A. Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico. Viruses. 2020; 12(11):1230. https://doi.org/10.3390/v12111230

Chicago/Turabian Style

Posadas-Mondragón, Araceli, José L. Aguilar-Faisal, Gerardo Zuñiga, Jonathan J. Magaña, José A. Santiago-Cruz, Edith Guillén-Salomón, Verónica Alcántara-Farfán, María L. Arellano-Flores, Juan S. Salas-Benito, Rocío M. Neri-Bazán, Lucero Luna-Rojas, Amanda M. Avila-Trejo, and Adolfo Chávez-Negrete. 2020. "Association of Genetic Polymorphisms in TLR3, TLR4, TLR7, and TLR8 with the Clinical Forms of Dengue in Patients from Veracruz, Mexico" Viruses 12, no. 11: 1230. https://doi.org/10.3390/v12111230

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