RNase L Is Involved in Liposaccharide-Induced Lung Inflammation
1
Clinical Chemistry Program, Department of Chemistry, Cleveland State University, Cleveland, OH 44115, USA
2
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
3
Department of Pathology, University Hospitals Cleveland Medical Center, Cleveland, OH 44115, USA
4
Department of BGES, Cleveland State University, Cleveland, OH 44115, USA
5
Center for Gene Regulation in Health and Diseases, Cleveland State University, Cleveland, OH 44115, USA
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(1), 73; https://doi.org/10.3390/v12010073
Received: 8 November 2019
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Revised: 30 December 2019
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Accepted: 1 January 2020
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Published: 7 January 2020
(This article belongs to the Special Issue Viruses and the OAS-RNase L Pathway)
RNase L mediates interferon (IFN) function during viral infection and cell proliferation. Furthermore, the role of RNase L in the regulation of gene expression, cell apoptosis, autophagy, and innate immunity has been well established in the last decade. Tissue distribution reveals that RNase L is highly expressed in the lung and other organs. However, the physiological roles of RNase L in the lung are largely unknown. In this study, we found that polysaccharide (LPS)-induced acute lung injury (ALI) was remarkably intensified in mice deficient in RNase L compared to wild type mice under the same condition. Furthermore, we found that RNase L mediated the TLR4 signaling pathway, and regulated the expression of various pro- and anti-inflammatory genes in the lung tissue and blood. Most importantly, RNase L function in macrophages during LPS stimulation may be independent of the 2-5A system. These findings demonstrate a novel role of RNase L in the immune response via an atypical molecular mechanism.
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Keywords:
RNase L; LPS; Acute lung injury; TLR4
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MDPI and ACS Style
Wei, R.; Chen, G.; Algehainy, N.; Zeng, C.; Liu, C.; Liu, H.; Liu, W.; Stacey, D.; Zhou, A. RNase L Is Involved in Liposaccharide-Induced Lung Inflammation. Viruses 2020, 12, 73. https://doi.org/10.3390/v12010073
AMA Style
Wei R, Chen G, Algehainy N, Zeng C, Liu C, Liu H, Liu W, Stacey D, Zhou A. RNase L Is Involved in Liposaccharide-Induced Lung Inflammation. Viruses. 2020; 12(1):73. https://doi.org/10.3390/v12010073
Chicago/Turabian StyleWei, Ruhan, Guanmin Chen, Naseh Algehainy, Chun Zeng, Chunfang Liu, Hongli Liu, Wendy Liu, Dennis Stacey, and Aimin Zhou. 2020. "RNase L Is Involved in Liposaccharide-Induced Lung Inflammation" Viruses 12, no. 1: 73. https://doi.org/10.3390/v12010073
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