The Impact of Human Mobility on Regional and Global Efforts to Control HIV Transmission
Abstract
:1. Introduction
2. Methods
3. The Role of Cross-Border Coordination in Infection Control
4. Human Mobility and HIV
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Author (Year) | Relevant Aims | Results | Comments/Notes on Migration |
---|---|---|---|
Aibekova (2018) [29] | Analyze the distribution of HIV-1 subtype A in thirteen former Soviet Union countries | HIV-1 subtype A clusters are intermixed | Intermixed clusters indicate a possible role of migration-associated HIV transmission |
Castley (2017) [30] | Determine HIV-1 subtype distribution and phylogenetic structure in Australia between 2005 and 2012 | HIV-1 epidemic in Australia is characterized by an increasing prevalence of non-B subtype infections and an overall expanding subtype diversity | Migration and overseas travel are potentially associated with the increasing prevalence and subtype diversity of infections |
Chaillon (2017) [31] | Understand regional HIV epidemics, the viral transmission links between these epidemics, and risk groups across the Mesoamerican region | Infrequency of international clusters suggests moderate migration between HIV epidemics of various Mesoamerican countries, but analyses indicate that Central and Southern Mexico and Belize were significant sources of HIV transmission throughout Mesoamerica Evidence of significant viral migration within Mexico | Human migration or travel is assumed to be the cause of transmission links among individuals from different nations Such transmission links may impact the overall epidemic by bridging susceptible populations and resulting in onward transmission |
de Pina-Araujo (2015) [32] | Reconstruct the phylogenetic relationship, onset date, and dissemination routes of the HIV-1 subtype G clades present throughout Angola, Cape Verde, and Portugal | HIV-1 subtype G likely originated in Central Africa and dissemination to Western and West-Central Africa occurred about a decade later | The local dissemination of HIV-1 subtype G infections in Cape Verde and Portugal are shaped by historical and ongoing movement of human populations between Angola, Cape Verde, and Portugal |
Leroy (2008) [33] | To assess the frequency of travel-related illnesses among ill-returned travelers in one infectious diseases department in France | Of the 265 diagnoses made in travelers who returned with illness, there were 6 incident HIV cases | Travelers are susceptible to infections, which have the potential to be disseminated when they return to their home country |
Magiorkinis (2016) [34] | Clarify the global routes of the HIV epidemic & understand the influence of human activity on HIV dissemination | The American continent and the Caribbean drove the epidemic outward to other geographic locations through an initial random migration event and further subsequent migrations globally | Dissemination of HIV through specific migration routes are consistent with geopolitical factors that affected human activities during the last 50 years, including migration. This evidence supports the argument that epidemic control policies should be implemented at global scales |
Mehta (2015) [28] | Characterize HIV transmission networks in the San Diego–Tijuana region using HIV sequence and demographic data | Persistent bidirectional cross-border HIV transmission link groups across the border | Viral migrations of HIV across the border stemmed from recently formed transmission clusters, which may be indicative of ongoing cross-border transmission The HIV epidemic is relevant and important to at-risk communities on both sides of a border |
Paraskevis (2009) [35] | Infer the migration history of HIV-1 subtype B among 17 countries in Europe | In most countries, the epidemic was introduced by multiple sources and subsequently spread within local networks; considerable differences between countries are present | Considering the pathways of viral spread together with the geographic distributions of viral phylogenies, intervention strategies should also address mobile populations |
Paraskevis (2017) [36] | Estimate the proportion of postmigration HIV-1 transmissions among migrants who inject drugs & infer whether postmigration transmission occurs more frequently through contacts with other migrants who inject drugs or through contacts with Greek injection drug users | A majority of HIV-1 infections in migrant injection drug users were acquired after migrants moved to Greece Transmission of HIV-1 occurs more frequently through contacts between migrants | Migrant populations are a priority for targeting HIV prevention efforts, as there exists significant transmission networking among migrants subsequent to their migration |
Paraskevis (2019) [37] | Identify and characterize molecular transmission clusters using molecular phylogenetic analyses & examine impact of clinical and demographic factors on regional phylogenetic clustering | Local populations are more likely to be infected within their own country, as reflected by the finding that subtype B infections have a higher probability of belonging to a molecular transmission cluster | Growth of regional HIV-1 epidemics is mainly associated with recent molecular transmission clusters compared to established cases |
Parczewski (2014) [38] | Investigate the HIV sequence variability among travel-associated cases with reported infection outside of Poland and trace the country of origin where infected was transmitted | Import of HIV-1 non-B subtype variants, including recombinant viral forms, is frequent among travelers | Introduction of HIV into the local population by immigrating travelers may contribute to an increasing number of circulating variants and viral diversification, while posing a risk of exponential infection spread in the population |
Pieniazek (1998) [39] | Determine the spread of HIV-subtype pattern in Lebanon, where the disease is not endemic but slowly increasing and where there is frequent population movement to and from other countries | Phylogenetic clusters used to track molecular and epidemiologic data indicate multiple HIV subtype introductions within Lebanon, and indicate that most male patients were infected abroad with the HIV-1 strains most common in the geographic location that they traveled to | Results show genetic variations in HIV within Lebanon and the discovery of new HIV-subtypes which indicate extreme heterogeneity of HIV subtypes in Lebanon |
Rasmussen (2018) [40] | Quantify the contribution of local viral transmission versus external introductions to overall HIV incidence | The majority of samples are interspersed throughout clades composed predominantly of external samples, indicating that many independent introduction events have occurred into the local population from elsewhere | External viral introductions play a large role in sustaining high HIV incidence, which confirms the important role of human mobility in HIV dissemination |
Schlagenhauf (2015) [41] | Assess available European surveillance data for travel-related illnesses to profile imported infections, track trends, identify risk groups, and assess the usefulness of pre-travel advice | Migration within Europe was associated with HIV/AIDS infections, among several other infections Pre-travel consultation was associated with significantly lower proportionate morbidity ratios for HIV/AIDS | The profile of travel-related infections varies according to the traveler type, migration trends, and the purpose of travel Pre-travel advice is useful for reduction of proportional morbidity with several infections, including HIV/AIDS |
Sinka (2003) [42] | Describe the epidemiology of HIV infection acquired in Africa and among African communities in the United Kingdom | African-acquired HIV infections diagnosed in the United Kingdom by 2001 make up about 21% of all reported infections and continue to increase rapidly specific to different regions within Africa | Early diagnosis of HIV infection is an important component of intervention to prevent transmission, but migration, diagnosis of long-standing infection, and incident cases are potential influences that should be accounted for in order to lower the burden of HIV infection |
Skar (2011) [43] | Investigate the dynamics of HIV-1 transmission among injection drug users during the outbreak in Stockholm & whether the outbreak could be due to the introduction of a new, more transmissible HIV-1 variant | The HIV outbreak that took place in Stockholm resulted from an imported variant | The outbreak was likely caused by the introduction of HIV into a network of injection drug users who were previously uninfected, which poses a valuable avenue for preventive efforts |
Takebe (2014) [44] | Explore possible linkages between the HIV epidemics in East Asia and those in the rest of the world | HIV subtype B variant that was common among Japanese MSM was detected worldwide, suggesting that specific subgroups may have been circulating locally before disseminating to other countries through global contact networks | Viral migration is bidirectional, as seen by trends in countries whose HIV epidemics have been considered a result of imported viruses, but have demonstrated exportation of specific HIV lineages |
von Wyl (2011) [45] | Examine the possibility of locating evidence for ongoing non-B transmission in Switzerland by identifying possible transmission pairs | Migration has a greater contribution to newly diagnosed non-B subtype HIV-1 infections among Africans compared to domestic transmission | Migration and domestic transmission both play a role in the epidemiology and transmission of non-B subtype HIV-1 A fraction of all non-B infections diagnosed in Switzerland could be prevented by local interventions To contain HIV dissemination, awareness should be raised among immigrants and Swiss individuals with partners from countries where HIV is endemic |
Wang, X (2015) [46] | Determine efficiency of using inferred network characteristics to target prevention interventions | The efficiency of targeting prevention efforts according to the number of network connections was higher than if not targeting such efforts | Using network connectivity information to administer preventive treatment may be an efficient way to deliver prevention interventions and will aid in lowering rates of HIV dissemination |
Wang, Y (2015) [47] | Assess HIV-1 prevalence and subtype distribution of entry travelers at the HeKou port, a major land port between Yunnan and Vietnam, from 2003 to 2012 | Trends of the HIV-1 molecular epidemiology among cross-border travelers within the HeKou port highlights the importance of continually monitoring new trends of the HIV epidemic and emerging novel recombinants, particularly among migrating populations | To prevent transmission of infectious pathogens, extended epidemiologic surveillance should be implemented at borders, especially where cross-border populations have particularly high mobility |
Wertheim (2014) [48] | Analyze global HIV-1 transmission patterns through construction of HIV-1 transmission clusters using only close genetic links to identify potential transmission partners | Individuals from 68% of included countries/regions had potential transmission partner(s) from another country/region | The extent of international linkage among HIV subtypes suggests the need to consider the global diversity in HIV when describing epidemics |
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Eshraghian, E.A.; Ferdos, S.N.; Mehta, S.R. The Impact of Human Mobility on Regional and Global Efforts to Control HIV Transmission. Viruses 2020, 12, 67. https://doi.org/10.3390/v12010067
Eshraghian EA, Ferdos SN, Mehta SR. The Impact of Human Mobility on Regional and Global Efforts to Control HIV Transmission. Viruses. 2020; 12(1):67. https://doi.org/10.3390/v12010067
Chicago/Turabian StyleEshraghian, Emily A., Sepideh N. Ferdos, and Sanjay R. Mehta. 2020. "The Impact of Human Mobility on Regional and Global Efforts to Control HIV Transmission" Viruses 12, no. 1: 67. https://doi.org/10.3390/v12010067
APA StyleEshraghian, E. A., Ferdos, S. N., & Mehta, S. R. (2020). The Impact of Human Mobility on Regional and Global Efforts to Control HIV Transmission. Viruses, 12(1), 67. https://doi.org/10.3390/v12010067