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Infection Load and Prevalence of Novel Viruses Identified from the Bank Vole Do Not Associate with Exposure to Environmental Radioactivity

1
Finland Ecology and Genetics Research Unit, University of Oulu, 90014 Oulu, Finland
2
Department of Biological and Environmental Science, University of Jyväskylä, 40014 Jyväskylä, Finland
3
National Research Center for Radiation Medicine of the National Academy of Medical Science, 02000 Kyiv, Ukraine
*
Author to whom correspondence should be addressed.
Viruses 2020, 12(1), 44; https://doi.org/10.3390/v12010044
Received: 5 December 2019 / Revised: 27 December 2019 / Accepted: 27 December 2019 / Published: 30 December 2019
(This article belongs to the Special Issue Virus Ecology and Evolution: Current Research and Future Directions)
Bank voles (Myodes glareolus) are host to many zoonotic viruses. As bank voles inhabiting areas contaminated by radionuclides show signs of immunosuppression, resistance to apoptosis, and elevated DNA repair activity, we predicted an association between virome composition and exposure to radionuclides. To test this hypothesis, we studied the bank vole virome in samples of plasma derived from animals inhabiting areas of Ukraine (contaminated areas surrounding the former nuclear power plant at Chernobyl, and uncontaminated areas close to Kyiv) that differed in level of environmental radiation contamination. We discovered four strains of hepacivirus and four new virus sequences: two adeno-associated viruses, an arterivirus, and a mosavirus. However, viral prevalence and viral load, and the ability to cause a systemic infection, was not dependent on the level of environmental radiation. View Full-Text
Keywords: plasma viromes; bank vole; adeno-associated virus; mosavirus; arterivirus; environmental radiation; next-generation sequencing plasma viromes; bank vole; adeno-associated virus; mosavirus; arterivirus; environmental radiation; next-generation sequencing
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Kesäniemi, J.; Lavrinienko, A.; Tukalenko, E.; Mappes, T.; Watts, P.C.; Jurvansuu, J. Infection Load and Prevalence of Novel Viruses Identified from the Bank Vole Do Not Associate with Exposure to Environmental Radioactivity. Viruses 2020, 12, 44.

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