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Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses

Department of Systems Biotechnology, Chung-Ang University, Anseong 17546, Korea
Fundamental Microbiology and Pathogenicity Laboratory, UMR 5234 CNRS-University of Bordeaux, 33076 Bordeaux, France
Viral DNA Integration and Chromatin Dynamics Network (DyNAVir), 33076 Bordeaux, France
Author to whom correspondence should be addressed.
Present address: Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA.
Viruses 2019, 11(9), 770;
Received: 6 August 2019 / Revised: 19 August 2019 / Accepted: 20 August 2019 / Published: 22 August 2019
(This article belongs to the Special Issue Spumaretroviruses)
Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes a prime target for antiretroviral therapy. This activity, conserved among retroviruses and long terminal repeat (LTR) retrotransposons, involves a viral nucleoprotein complex called intasome. In the last decade, a plethora of structural insights on retroviral DNA integration arose from the study of FV. Here, we review the biochemistry and the structural features of the FV integration apparatus and will also discuss the mechanism of action of strand transfer inhibitors. View Full-Text
Keywords: retrovirus; foamy virus; integrase; integration retrovirus; foamy virus; integrase; integration
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Lee, G.-E.; Mauro, E.; Parissi, V.; Shin, C.-G.; Lesbats, P. Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses. Viruses 2019, 11, 770.

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