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Host Cellular Receptors for the Peste des Petits Ruminant Virus

1
State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, China
2
Deutsche Gesellschaft für Internationale Zusammenarbeit (GIZ) GmbH, P.O. Box 1457, Kathmandu, Nepal
3
CAAS-ILRI Joint Laboratory for Ruminant Disease Control, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou 730046, China
*
Author to whom correspondence should be addressed.
Viruses 2019, 11(8), 729; https://doi.org/10.3390/v11080729
Received: 30 May 2019 / Revised: 5 August 2019 / Accepted: 6 August 2019 / Published: 8 August 2019
(This article belongs to the Section Animal Viruses)
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PDF [917 KB, uploaded 8 August 2019]
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Abstract

Peste des Petits Ruminant (PPR) is an important transboundary, OIE-listed contagious viral disease of primarily sheep and goats caused by the PPR virus (PPRV), which belongs to the genus Morbillivirus of the family Paramyxoviridae. The mortality rate is 90–100%, and the morbidity rate may reach up to 100%. PPR is considered economically important as it decreases the production and productivity of livestock. In many endemic poor countries, it has remained an obstacle to the development of sustainable agriculture. Hence, proper control measures have become a necessity to prevent its rapid spread across the world. For this, detailed information on the pathogenesis of the virus and the virus host interaction through cellular receptors needs to be understood clearly. Presently, two cellular receptors; signaling lymphocyte activation molecule (SLAM) and Nectin-4 are known for PPRV. However, extensive information on virus interactions with these receptors and their impact on host immune response is still required. Hence, a thorough understanding of PPRV receptors and the mechanism involved in the induction of immunosuppression is crucial for controlling PPR. In this review, we discuss PPRV cellular receptors, viral host interaction with cellular receptors, and immunosuppression induced by the virus with reference to other Morbilliviruses. View Full-Text
Keywords: Morbillivirus; Nectin-4; PPRV; SLAM Morbillivirus; Nectin-4; PPRV; SLAM
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Prajapati, M.; Alfred, N.; Dou, Y.; Yin, X.; Prajapati, R.; Li, Y.; Zhang, Z. Host Cellular Receptors for the Peste des Petits Ruminant Virus. Viruses 2019, 11, 729.

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