Next Article in Journal
Ts2631 Endolysin from the Extremophilic Thermus scotoductus Bacteriophage vB_Tsc2631 as an Antimicrobial Agent against Gram-Negative Multidrug-Resistant Bacteria
Next Article in Special Issue
Discovery of Four Novel Viruses Associated with Flower Yellowing Disease of Green Sichuan Pepper (Zanthoxylum armatum) by Virome Analysis
Previous Article in Journal
Hepatitis B Virus X Gene Differentially Modulates Subgenotype F1b and F4 Replication
Previous Article in Special Issue
Unravelling the Single-Stranded DNA Virome of the New Zealand Blackfly
Open AccessReview

Human Virome and Disease: High-Throughput Sequencing for Virus Discovery, Identification of Phage-Bacteria Dysbiosis and Development of Therapeutic Approaches with Emphasis on the Human Gut

Diversigen Inc., 2450 Holcombe Blvd, Suite BCMA, 77021 Houston, TX, USA
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(7), 656; https://doi.org/10.3390/v11070656
Received: 19 June 2019 / Revised: 14 July 2019 / Accepted: 15 July 2019 / Published: 18 July 2019
(This article belongs to the Special Issue Viromics: Approaches, Advances, and Applications)
The virome is comprised of endogenous retroviruses, eukaryotic viruses, and bacteriophages and is increasingly being recognized as an essential part of the human microbiome. The human virome is associated with Type-1 diabetes (T1D), Type-2 diabetes (T2D), Inflammatory Bowel Disease (IBD), Human Immunodeficiency Virus (HIV) infection, and cancer. Increasing evidence also supports trans-kingdom interactions of viruses with bacteria, small eukaryotes and host in disease progression. The present review focuses on virus ecology and biology and how this translates mostly to human gut virome research. Current challenges in the field and how the development of bioinformatic tools and controls are aiding to overcome some of these challenges are also discussed. Finally, the present review also focuses on how human gut virome research could result in translational and clinical studies that may facilitate the development of therapeutic approaches. View Full-Text
Keywords: microbiome; phage therapy; viral mock communities; virome microbiome; phage therapy; viral mock communities; virome
Show Figures

Figure 1

MDPI and ACS Style

Santiago-Rodriguez, T.M.; Hollister, E.B. Human Virome and Disease: High-Throughput Sequencing for Virus Discovery, Identification of Phage-Bacteria Dysbiosis and Development of Therapeutic Approaches with Emphasis on the Human Gut. Viruses 2019, 11, 656.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop