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Open AccessArticle

Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study

Service d’hématologie-greffe, Hôpital Saint-Louis, Université Paris-Diderot, 75010 Paris, France
Service de virologie, Hôpital Paul-Brousse, 94804 Villejuif, France
INSERM 1193 et CNR hépatite A et E, Université Paris-Sud, 94804 Villejuif, France
Service d’hépatologie, Hôpital Cochin, Université Paris Descartes, INSERM U1223, Institut Pasteur, 75014 Paris, France
Service d’hématologie, Hôpital La Pitié-Salpêtrière, 75013 Paris, France
Service d’hématologie, Centre Hospitalier Universitaire, 06000 Nice, France
Service d’hématologie, CHU Bordeaux, 33600 Pessac, France
Service d’hématologie, Hôpital Percy, 92140 Clamart, France
Service d’hématologie, CHU, 37000 Tours, France
Laboratoire de virologie et CNR hépatite E, CHU, 31000 Toulouse, France
Service d’hématologie, CHU, 31000 Toulouse, France
Author to whom correspondence should be addressed.
Viruses 2019, 11(7), 622;
Received: 24 April 2019 / Revised: 2 July 2019 / Accepted: 4 July 2019 / Published: 5 July 2019
(This article belongs to the Special Issue Hepatitis E Virus)
Usually self-limited, hepatitis E virus (HEV) infection may evolve to chronicity and cirrhosis in immunosuppressed patients. HEV infection has been described in solid-organ transplantation and hematology patients, but for allogeneic hematopoietic stem cell transplant (alloHSCT) recipients, only small cohorts are available. This retrospective nationwide multi-center series aimed to describe HEV diagnostic practices in alloHSCT French centers, and the course of infection in the context of alloHSCT. Twenty-nine out of 37 centers participated. HEV search in case of liver function tests (LFT) abnormalities was never performed in 24% of centers, occasionally in 55%, and systematically in 21%. Twenty-five cases of active HEV infection were diagnosed in seven centers, all because of LFT abnormalities, by blood nucleic acid testing. HEV infection was diagnosed in three patients before alloHSCT; HEV infection did not influence transplantation planning, and resolved spontaneously before or after alloHSCT. Twenty-two patients were diagnosed a median of 283 days after alloHSCT. Nine patients (41%) had spontaneous viral clearance, mostly after immunosuppressive treatment decrease. Thirteen patients (59%) received ribavirin, with sustained viral clearance in 11/12 evaluable patients. We observed three HEV recurrences but no HEV-related death or liver failure, nor evolution to cirrhosis. View Full-Text
Keywords: allogeneic hematopoietic stem transplantation; hepatitis E allogeneic hematopoietic stem transplantation; hepatitis E
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Xhaard, A.; Roque-Afonso, A.-M.; Mallet, V.; Ribaud, P.; Nguyen-Quoc, S.; Rohrlich, P.-S.; Tabrizi, R.; Konopacki, J.; Lissandre, S.; Abravanel, F.; Latour, R.P.; Huynh, A. Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study. Viruses 2019, 11, 622.

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