Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study
AbstractUsually self-limited, hepatitis E virus (HEV) infection may evolve to chronicity and cirrhosis in immunosuppressed patients. HEV infection has been described in solid-organ transplantation and hematology patients, but for allogeneic hematopoietic stem cell transplant (alloHSCT) recipients, only small cohorts are available. This retrospective nationwide multi-center series aimed to describe HEV diagnostic practices in alloHSCT French centers, and the course of infection in the context of alloHSCT. Twenty-nine out of 37 centers participated. HEV search in case of liver function tests (LFT) abnormalities was never performed in 24% of centers, occasionally in 55%, and systematically in 21%. Twenty-five cases of active HEV infection were diagnosed in seven centers, all because of LFT abnormalities, by blood nucleic acid testing. HEV infection was diagnosed in three patients before alloHSCT; HEV infection did not influence transplantation planning, and resolved spontaneously before or after alloHSCT. Twenty-two patients were diagnosed a median of 283 days after alloHSCT. Nine patients (41%) had spontaneous viral clearance, mostly after immunosuppressive treatment decrease. Thirteen patients (59%) received ribavirin, with sustained viral clearance in 11/12 evaluable patients. We observed three HEV recurrences but no HEV-related death or liver failure, nor evolution to cirrhosis. View Full-Text
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Xhaard, A.; Roque-Afonso, A.-M.; Mallet, V.; Ribaud, P.; Nguyen-Quoc, S.; Rohrlich, P.-S.; Tabrizi, R.; Konopacki, J.; Lissandre, S.; Abravanel, F.; Latour, R.P.; Huynh, A. Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study. Viruses 2019, 11, 622.
Xhaard A, Roque-Afonso A-M, Mallet V, Ribaud P, Nguyen-Quoc S, Rohrlich P-S, Tabrizi R, Konopacki J, Lissandre S, Abravanel F, Latour RP, Huynh A. Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study. Viruses. 2019; 11(7):622.Chicago/Turabian Style
Xhaard, Aliénor; Roque-Afonso, Anne-Marie; Mallet, Vincent; Ribaud, Patricia; Nguyen-Quoc, Stéphanie; Rohrlich, Pierre-Simon; Tabrizi, Reza; Konopacki, Johanna; Lissandre, Séverine; Abravanel, Florence; Latour, Régis P.; Huynh, Anne. 2019. "Hepatitis E and Allogeneic Hematopoietic Stem Cell Transplantation: A French Nationwide SFGM-TC Retrospective Study." Viruses 11, no. 7: 622.
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