Next Article in Journal
Conserved Residue Asn-145 in the C-Terminal Heptad Repeat Region of HIV-1 gp41 is Critical for Viral Fusion and Regulates the Antiviral Activity of Fusion Inhibitors
Next Article in Special Issue
The Clinical Perspective on Hepatitis E
Previous Article in Journal
Combining Viral Genetics and Statistical Modeling to Improve HIV-1 Time-of-Infection Estimation towards Enhanced Vaccine Efficacy Assessment
Previous Article in Special Issue
Animal Models for Hepatitis E Virus
Article Menu
Issue 7 (July) cover image

Export Article

Open AccessReview

Cell Culture Models for Hepatitis E Virus

Schaller Research Group at Department of Infectious Diseases and Virology, Heidelberg University Hospital, Cluster of Excellence CellNetworks, 69120 Heidelberg, Germany
Heidelberg Biosciences International Graduate School, Heidelberg University, 69120 Heidelberg, Germany
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Viruses 2019, 11(7), 608;
Received: 3 June 2019 / Revised: 24 June 2019 / Accepted: 29 June 2019 / Published: 3 July 2019
(This article belongs to the Special Issue Hepatitis E Virus)
PDF [1248 KB, uploaded 3 July 2019]
  |     |  


Despite a growing awareness, hepatitis E virus (HEV) remains understudied and investigations have been historically hampered by the absence of efficient cell culture systems. As a result, the pathogenesis of HEV infection and basic steps of the HEV life cycle are poorly understood. Major efforts have recently been made through the development of HEV infectious clones and cellular systems that significantly advanced HEV research. Here, we summarize these systems, discussing their advantages and disadvantages for HEV studies. We further capitalize on the need for HEV-permissive polarized cell models to better recapitulate the entire HEV life cycle and transmission. View Full-Text
Keywords: hepatitis E virus; cell culture systems; stem cells; hepatocyte polarization hepatitis E virus; cell culture systems; stem cells; hepatocyte polarization

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Fu, R.M.; Decker, C.C.; Dao Thi, V.L. Cell Culture Models for Hepatitis E Virus. Viruses 2019, 11, 608.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top