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Nucleocapsid Assembly of Baculoviruses

College of Bioscience and Biotechnology, Yangzhou University, Yangzhou 225009, China
Joint International Research Laboratory of Agriculture & Agri-Product Safety, Yangzhou University, Yangzhou 225009, China
Author to whom correspondence should be addressed.
Viruses 2019, 11(7), 595;
Received: 29 May 2019 / Revised: 27 June 2019 / Accepted: 30 June 2019 / Published: 1 July 2019
(This article belongs to the Special Issue Insect Viruses and Pest Management)
PDF [687 KB, uploaded 1 July 2019]


The baculovirus nucleocapsid is formed through a rod-like capsid encapsulating a genomic DNA molecule of 80~180 kbp. The viral capsid is a large oligomer composed of many copies of various protein subunits. The assembly of viral capsids is a complex oligomerization process. The timing of expression of nucleocapsid-related proteins, transport pathways, and their interactions can affect the assembly process of preformed capsids. In addition, the selection of viral DNA and the injection of the viral genome into empty capsids are the critical steps in nucleocapsid assembly. This paper reviews the replication and recombination of baculovirus DNA, expression and transport of capsid proteins, formation of preformed capsids, DNA encapsulation, and nucleocapsid formation. This review will provide a basis for further study of the nucleocapsid assembly mechanism of baculovirus. View Full-Text
Keywords: nucleocapsid assembly; baculovirus; preformed capsid; DNA packaging; capsid proteins nucleocapsid assembly; baculovirus; preformed capsid; DNA packaging; capsid proteins

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Zhao, S.; He, G.; Yang, Y.; Liang, C. Nucleocapsid Assembly of Baculoviruses. Viruses 2019, 11, 595.

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