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Open AccessReview

Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry

by Ruikun Du 1,2,3,*, Qinghua Cui 1,2,3 and Lijun Rong 4,*
1
College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China
2
Shandong Provincial Collaborative Innovation Center for Antiviral Traditional Chinese Medicine, Jinan 250355, China
3
Qingdao Academy of Chinese Medicinal Sciences, Shandong University of Traditional Chinese Medicine, Qingdao 266122, China
4
Department of Microbiology and Immunology, College of Medicine, University of Illinois at Chicago, Chicago, IL 60612, USA
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(5), 458; https://doi.org/10.3390/v11050458
Received: 30 April 2019 / Revised: 17 May 2019 / Accepted: 18 May 2019 / Published: 20 May 2019
(This article belongs to the Special Issue Viral Entry Pathways)
The hemagglutinin (HA) and neuraminidase (NA) of influenza A virus possess antagonistic activities on interaction with sialic acid (SA), which is the receptor for virus attachment. HA binds SA through its receptor-binding sites, while NA is a receptor-destroying enzyme by removing SAs. The function of HA during virus entry has been extensively investigated, however, examination of NA has long been focused to its role in the exit of progeny virus from infected cells, and the role of NA in the entry process is still under-appreciated. This review summarizes the current understanding of the roles of HA and NA in relation to each other during virus entry. View Full-Text
Keywords: influenza A virus; hemagglutinin; neuraminidase; virus entry influenza A virus; hemagglutinin; neuraminidase; virus entry
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MDPI and ACS Style

Du, R.; Cui, Q.; Rong, L. Competitive Cooperation of Hemagglutinin and Neuraminidase during Influenza A Virus Entry. Viruses 2019, 11, 458.

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