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Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines

VA-MD College of Veterinary Medicine, University of Maryland, College Park, MD 20742, USA
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Author to whom correspondence should be addressed.
Viruses 2019, 11(3), 300; https://doi.org/10.3390/v11030300
Received: 25 February 2019 / Revised: 19 March 2019 / Accepted: 22 March 2019 / Published: 26 March 2019
(This article belongs to the Special Issue Avian Respiratory Viruses)
Highly pathogenic avian influenza (HPAI) and Newcastle disease are economically important avian diseases worldwide. Effective vaccination is critical to control these diseases in poultry. Live attenuated Newcastle disease virus (NDV) vectored vaccines have been developed for bivalent vaccination against HPAI viruses and NDV. These vaccines have been generated by inserting the hemagglutinin (HA) gene of avian influenza virus into NDV genomes. In laboratory settings, several experimental NDV-vectored vaccines have protected specific pathogen-free chickens from mortality, clinical signs, and virus shedding against H5 and H7 HPAI viruses and NDV challenges. NDV-vectored H5 vaccines have been licensed for poultry vaccination in China and Mexico. Recently, an antigenically chimeric NDV vector has been generated to overcome pre-existing immunity to NDV in poultry and to provide early protection of poultry in the field. Prime immunization of one-day-old poults with a chimeric NDV vector followed by boosting with a conventional NDV vector has shown to protect broiler chickens against H5 HPAI viruses and a highly virulent NDV. This novel vaccination approach can provide efficient control of HPAI viruses in the field and facilitate poultry vaccination. View Full-Text
Keywords: highly pathogenic avian influenza virus; Newcastle disease virus; live attenuated NDV-vectored vaccines; chimeric NDV vector; poultry highly pathogenic avian influenza virus; Newcastle disease virus; live attenuated NDV-vectored vaccines; chimeric NDV vector; poultry
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Kim, S.-H.; Samal, S.K. Innovation in Newcastle Disease Virus Vectored Avian Influenza Vaccines. Viruses 2019, 11, 300.

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