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Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA Viruses: A Complex Story

1
Research Center for Health Sciences and Biomedicine (CICSaB), Universidad Autónoma de San Luis Potosí (UASLP), Av. Sierra Leona 550 Lomas 2da Seccion, 72810 San Luis Potosi, Mexico
2
Department of Sciences, Universidad Autónoma de San Luis Potosí (UASLP), Av. Chapultepec 1570, Privadas del Pedregal, 78295 San Luis Potosi, Mexico
Viruses 2019, 11(3), 253; https://doi.org/10.3390/v11030253
Received: 14 February 2019 / Revised: 7 March 2019 / Accepted: 8 March 2019 / Published: 13 March 2019
(This article belongs to the Special Issue Viruses Ten-Year Anniversary)
The packaging of genomic RNA in positive-sense single-stranded RNA viruses is a key part of the viral infectious cycle, yet this step is not fully understood. Unlike double-stranded DNA and RNA viruses, this process is coupled with nucleocapsid assembly. The specificity of RNA packaging depends on multiple factors: (i) one or more packaging signals, (ii) RNA replication, (iii) translation, (iv) viral factories, and (v) the physical properties of the RNA. The relative contribution of each of these factors to packaging specificity is different for every virus. In vitro and in vivo data show that there are different packaging mechanisms that control selective packaging of the genomic RNA during nucleocapsid assembly. The goals of this article are to explain some of the key experiments that support the contribution of these factors to packaging selectivity and to draw a general scenario that could help us move towards a better understanding of this step of the viral infectious cycle. View Full-Text
Keywords: (+)ssRNA viruses; RNA packaging; virion assembly; packaging signals; RNA replication (+)ssRNA viruses; RNA packaging; virion assembly; packaging signals; RNA replication
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MDPI and ACS Style

Comas-Garcia, M. Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA Viruses: A Complex Story. Viruses 2019, 11, 253. https://doi.org/10.3390/v11030253

AMA Style

Comas-Garcia M. Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA Viruses: A Complex Story. Viruses. 2019; 11(3):253. https://doi.org/10.3390/v11030253

Chicago/Turabian Style

Comas-Garcia, Mauricio. 2019. "Packaging of Genomic RNA in Positive-Sense Single-Stranded RNA Viruses: A Complex Story" Viruses 11, no. 3: 253. https://doi.org/10.3390/v11030253

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