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Viruses 2019, 11(2), 129; https://doi.org/10.3390/v11020129

A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations

1
Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China
2
Bioinformatics and Computational Biology Program, School of Systems Biology, George Mason University, Manassas, VA 20110, USA
3
Chemistry Department, American University, Washington, DC 20016, USA
4
Department of Microbiology, The University of Hong Kong, Hong Kong, China
5
Guangzhou Key Laboratory of Virology, Institute of Medical Microbiology, Jinan University, Guangzhou 510632, China
*
Authors to whom correspondence should be addressed.
Received: 18 January 2019 / Accepted: 30 January 2019 / Published: 31 January 2019
(This article belongs to the Section Animal Viruses)
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Abstract

Human adenovirus type 4 (HAdV-E4), which is intriguingly limited to military populations, causes acute respiratory disease with demonstrated morbidity and mortality implications. This respiratory pathogen contains genome identity with chimpanzee adenoviruses, indicating zoonotic origins. A signature of these “old” HAdV-E4 is the absence of a critical replication motif, NF-I, which is found in all HAdV respiratory pathogens and most HAdVs. However, our recent survey of flu-like disease in children in Hong Kong reveals that the emergent HAdV-E4 pathogens circulating in civilian populations contain NF-I, indicating recombination and reflecting host-adaptation that enables the “new” HAdV-E4 to replicate more efficiently in human cells and foretells more potential HAdV-E4 outbreaks in immune-naïve civilian populations. Special attention should be paid by clinicians to this emergent and recombinant HAdV-E4 circulating in civilian populations. View Full-Text
Keywords: zoonosis; host adaptation; evolution; genome recombination; respiratory pathogens; civilian populations; human adenovirus type 4 zoonosis; host adaptation; evolution; genome recombination; respiratory pathogens; civilian populations; human adenovirus type 4
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Zhang, J.; Kang, J.; Dehghan, S.; Sridhar, S.; Lau, S.K.P.; Ou, J.; Woo, P.C.Y.; Zhang, Q.; Seto, D. A Survey of Recent Adenoviral Respiratory Pathogens in Hong Kong Reveals Emergent and Recombinant Human Adenovirus Type 4 (HAdV-E4) Circulating in Civilian Populations. Viruses 2019, 11, 129.

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