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Viruses 2019, 11(2), 106; https://doi.org/10.3390/v11020106

Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries

1
Penn Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
2
Department of Microbiology and Immunology, Faculty of Pharmacy, Cairo University, Kasr El-Aini, Cairo 11562, Egypt
Received: 4 January 2019 / Revised: 24 January 2019 / Accepted: 25 January 2019 / Published: 27 January 2019
(This article belongs to the Special Issue CSV2018: The 2nd symposium of the Canadian Society for Virology (CSV))
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Abstract

Virology has played an essential role in deciphering many immunological phenomena, thus shaping our current understanding of the immune system. Animal models of viral infection and human viral infections were both important tools for immunological discoveries. This review discusses two immunological breakthroughs originally identified with the help of the lymphocytic choriomeningitis virus (LCMV) model; immunological restriction by major histocompatibility complex and immunotherapy using checkpoint blockade. In addition, we discuss related discoveries such as development of tetramers, viral escape mutation, and the phenomenon of T-cell exhaustion. View Full-Text
Keywords: LCMV; HIV; HCV; MHC restriction; tetramer; checkpoint blockade; immunotherapy; T cell exhaustion LCMV; HIV; HCV; MHC restriction; tetramer; checkpoint blockade; immunotherapy; T cell exhaustion
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Abdel-Hakeem, M.S. Viruses Teaching Immunology: Role of LCMV Model and Human Viral Infections in Immunological Discoveries. Viruses 2019, 11, 106.

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