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Open AccessCommunication

IFNα and IFNγ Impede Marek’s Disease Progression

1
Institute of Virology, Freie Universität Berlin, 14163 Berlin, Germany
2
Department of Veterinary Sciences, Ludwig-Maximilians-Universität München, 80539 Munich, Germany
3
Lohmann Animal Health, 27472 Cuxhaven, Germany
*
Authors to whom correspondence should be addressed.
Viruses 2019, 11(12), 1103; https://doi.org/10.3390/v11121103
Received: 1 November 2019 / Revised: 25 November 2019 / Accepted: 27 November 2019 / Published: 28 November 2019
(This article belongs to the Section Animal Viruses)
Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow field strains to circulate and evolve in vaccinated flocks. Therefore, there is a need for improved vaccines and for a better understanding of innate and adaptive immune responses against MDV infections. Interferons (IFNs) play important roles in the innate immune defenses against viruses and induce upregulation of a cellular antiviral state. In this report, we quantified the potent antiviral effect of IFNα and IFNγ against MDV infections in vitro. Moreover, we demonstrate that both cytokines can delay Marek’s disease onset and progression in vivo. Additionally, blocking of endogenous IFNα using a specific monoclonal antibody, in turn, accelerated disease. In summary, our data reveal the effects of IFNα and IFNγ on MDV infection and improve our understanding of innate immune responses against this oncogenic virus. View Full-Text
Keywords: Marek’s disease virus; recombinant interferons; chicken cytokines; innate immunity; antiviral host defense; antitumor immune response Marek’s disease virus; recombinant interferons; chicken cytokines; innate immunity; antiviral host defense; antitumor immune response
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Bertzbach, L.D.; Harlin, O.; Härtle, S.; Fehler, F.; Vychodil, T.; Kaufer, B.B.; Kaspers, B. IFNα and IFNγ Impede Marek’s Disease Progression. Viruses 2019, 11, 1103.

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