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Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses

Institute of Life Sciences, Jiangsu University, Zhenjiang 212013, Jiangsu, China
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Author to whom correspondence should be addressed.
Viruses 2019, 11(11), 1035; https://doi.org/10.3390/v11111035
Received: 13 October 2019 / Revised: 30 October 2019 / Accepted: 31 October 2019 / Published: 7 November 2019
(This article belongs to the Section Insect Viruses)
Typical viral propagation involves sequential viral entry, uncoating, replication, gene transcription and protein synthesis, and virion assembly and release. Some viral proteins must be transported into host nucleus to facilitate viral propagation, which is essential for the production of mature virions. During the transport process, nuclear localization signals (NLSs) play an important role in guiding target proteins into nucleus through the nuclear pore. To date, some classical nuclear localization signals (cNLSs) and non-classical NLSs (ncNLSs) have been identified in a number of viral proteins. These proteins are involved in viral replication, expression regulation of viral genes and virion assembly. Moreover, other proteins are transported into nucleus with unknown mechanisms. This review highlights our current knowledge about the nuclear trafficking of cellular proteins associated with viral propagation. View Full-Text
Keywords: viral propagation; NLSs; cNLSs; ncNLSs; viral replication; expression regulation; virion assembly viral propagation; NLSs; cNLSs; ncNLSs; viral replication; expression regulation; virion assembly
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MDPI and ACS Style

Li, G.; Qi, X.; Hu, Z.; Tang, Q. Mechanisms Mediating Nuclear Trafficking Involved in Viral Propagation by DNA Viruses. Viruses 2019, 11, 1035.

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