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Emerging Role of LY6E in Virus–Host Interactions

by 1,2,† and 1,2,3,4,*
Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH 43210, USA
Viruses and Emerging Pathogens Program, Infectious Diseases Institute, The Ohio State University, Columbus, OH 43210, USA
Author to whom correspondence should be addressed.
Present address: Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA.
Viruses 2019, 11(11), 1020;
Received: 17 October 2019 / Revised: 30 October 2019 / Accepted: 1 November 2019 / Published: 3 November 2019
(This article belongs to the Special Issue Mechanisms of Viral Fusion and Applications in Antivirals)
As a canonical lymphocyte antigen-6/urokinase-type plasminogen activator receptor Ly6/uPAR family protein, lymphocyte antigen 6 complex, locus E (LY6E), plays important roles in immunological regulation, T cell physiology, and oncogenesis. Emerging evidence indicates that LY6E is also involved in the modulation of viral infection. Consequently, viral infection and associated pathogenesis have been associated with altered LY6E gene expression. The interaction between viruses and the host immune system has offered insights into the biology of LY6E. In this review, we summarize the current knowledge of LY6E in the context of viral infection, particularly viral entry. View Full-Text
Keywords: Ly6/uPAR; viruses; LY6E; virus–host interactions Ly6/uPAR; viruses; LY6E; virus–host interactions
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Yu, J.; Liu, S.-L. Emerging Role of LY6E in Virus–Host Interactions. Viruses 2019, 11, 1020.

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