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Molecular Identification of a Novel Hantavirus in Malaysian Bronze Tube-Nosed Bats (Murina aenea)

Szentágothai Research Centre, Virological Research Group Pécs Hungary, University of Pécs, 7624 Pécs, Hungary
Institute of Biology, Faculty of Sciences, University of Pécs, 7622 Pécs, Hungary
Department of Zoology, Hungarian Natural History Museum, 1083 Budapest, Hungary
Faculty of Resource Science and Technology, UniversitiMalaysia Sarawak, Kota Samarahan 94300, Malaysia
Microbial Biotechnology Research Group, Szentágothai Research Centre, University of Pécs, 7624 Pécs, Hungary
Szentágothai Research Centre, Bioinformatics Core Facility, Bioinformatics Research Group, University of Pécs, 7624 Pécs, Hungary
Authors to whom correspondence should be addressed.
Viruses 2019, 11(10), 887;
Received: 31 July 2019 / Revised: 18 September 2019 / Accepted: 19 September 2019 / Published: 21 September 2019
(This article belongs to the Special Issue Hantaviruses)
In the past ten years, several novel hantaviruses were discovered in shrews, moles, and bats, suggesting the dispersal of hantaviruses in many animal taxa other than rodents during their evolution. Interestingly, the coevolutionary analyses of most recent studies have raised the possibility that nonrodents may have served as the primordial mammalian host and harboured the ancestors of rodent-borne hantaviruses as well. The aim of our study was to investigate the presence of hantaviruses in bat lung tissue homogenates originally collected for taxonomic purposes in Malaysia in 2015. Hantavirus-specific nested RT-PCR screening of 116 samples targeting the L segment of the virus has revealed the positivity of two lung tissue homogenates originating from two individuals, a female and a male of the Murina aenea bat species collected at the same site and sampling occasion. Nanopore sequencing of hantavirus positive samples resulted in partial genomic data from S, M, and L genome segments. The obtained results indicate molecular evidence for hantaviruses in the M. aenea bat species. Sequence analysis of the PCR amplicon and partial genome segments suggests that the identified virus may represent a novel species in the Mobatvirus genus within the Hantaviridae family. Our results provide additional genomic data to help extend our knowledge about the evolution of these viruses. View Full-Text
Keywords: Sarawak mobatvirus; MinION; Tb1-Lu; Mobatvirus; one health concept Sarawak mobatvirus; MinION; Tb1-Lu; Mobatvirus; one health concept
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Zana, B.; Kemenesi, G.; Buzás, D.; Csorba, G.; Görföl, T.; Khan, F.A.A.; Tahir, N.F.D.A.; Zeghbib, S.; Madai, M.; Papp, H.; Földes, F.; Urbán, P.; Herczeg, R.; Tóth, G.E.; Jakab, F. Molecular Identification of a Novel Hantavirus in Malaysian Bronze Tube-Nosed Bats (Murina aenea). Viruses 2019, 11, 887.

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