Mutation and Epistasis in Influenza Virus Evolution
AbstractInfluenza remains a persistent public health challenge, because the rapid evolution of influenza viruses has led to marginal vaccine efficacy, antiviral resistance, and the annual emergence of novel strains. This evolvability is driven, in part, by the virus’s capacity to generate diversity through mutation and reassortment. Because many new traits require multiple mutations and mutations are frequently combined by reassortment, epistatic interactions between mutations play an important role in influenza virus evolution. While mutation and epistasis are fundamental to the adaptability of influenza viruses, they also constrain the evolutionary process in important ways. Here, we review recent work on mutational effects and epistasis in influenza viruses. View Full-Text
Share & Cite This Article
Lyons, D.M.; Lauring, A.S. Mutation and Epistasis in Influenza Virus Evolution. Viruses 2018, 10, 407.
Lyons DM, Lauring AS. Mutation and Epistasis in Influenza Virus Evolution. Viruses. 2018; 10(8):407.Chicago/Turabian Style
Lyons, Daniel M.; Lauring, Adam S. 2018. "Mutation and Epistasis in Influenza Virus Evolution." Viruses 10, no. 8: 407.
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.