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Viruses 2018, 10(8), 408;

The Human Cytomegalovirus, from Oncomodulation to Oncogenesis

Department Pathogens & Inflammation-EPILAB, UPRES EA4266, University of Bourgogne France-Comté (UBFC), F-25030 Besancon, France
Department of Virology, CHRU Besancon, F-25030 Besancon, France
Received: 30 June 2018 / Revised: 30 July 2018 / Accepted: 1 August 2018 / Published: 3 August 2018
(This article belongs to the Special Issue Recent Advances in Cytomegalovirus Research)
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Besides its well-described impact in immunosuppressed patients, the role of human cytomegalovirus (HCMV) in the pathogenesis of cancer has been more recently investigated. In cancer, HCMV could favor the progression and the spread of the tumor, a paradigm named oncomodulation. Although oncomodulation could account for part of the protumoral effect of HCMV, it might not explain the whole impact of HCMV infection on the tumor and the tumoral microenvironment. On the contrary cases have been reported where HCMV infection slows down the progression and the spread of the tumor. In addition, HCMV proteins have oncogenic properties per se, HCMV activates pro-oncogenic pathways in infected cells, and recently the direct transformation of cells following HCMV infection has been described, which gave rise to tumors when injected in mice. Thus, beyond the oncomodulation model, this review will assess the direct transforming role of HMCV-infected cells and the potential classification of HCMV as an oncovirus. View Full-Text
Keywords: HCMV; cancer; CTH cells; oncomodulation; oncovirus HCMV; cancer; CTH cells; oncomodulation; oncovirus

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Herbein, G. The Human Cytomegalovirus, from Oncomodulation to Oncogenesis. Viruses 2018, 10, 408.

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