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From Host to Phage Metabolism: Hot Tales of Phage T4’s Takeover of E. coli

1
Bacteriophage Lab, The Evergreen State College, Olympia, WA 98505, USA
2
Department of Biosystems, KU Leuven, Leuven 3000, Belgium
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(7), 387; https://doi.org/10.3390/v10070387
Received: 28 May 2018 / Revised: 26 June 2018 / Accepted: 26 June 2018 / Published: 21 July 2018
(This article belongs to the Special Issue Phage-Host Interactions)
The mechanisms by which bacteriophage T4 converts the metabolism of its E. coli host to one dedicated to progeny phage production was the subject of decades of intense research in many labs from the 1950s through the 1980s. Presently, a wide range of phages are starting to be used therapeutically and in many other applications, and also the range of phage sequence data available is skyrocketing. It is thus important to re-explore the extensive available data about the intricacies of the T4 infection process as summarized here, expand it to looking much more broadly at other genera of phages, and explore phage infections using newly-available modern techniques and a range of appropriate environmental conditions. View Full-Text
Keywords: bacteriophage; Tevenvirinae; radiolabeling; genomic map; 2-D polyacrylamide gel electrophoresis; NEPHGE-SDS PAGE bacteriophage; Tevenvirinae; radiolabeling; genomic map; 2-D polyacrylamide gel electrophoresis; NEPHGE-SDS PAGE
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Kutter, E.; Bryan, D.; Ray, G.; Brewster, E.; Blasdel, B.; Guttman, B. From Host to Phage Metabolism: Hot Tales of Phage T4’s Takeover of E. coli. Viruses 2018, 10, 387.

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