Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains
Abstract
:1. Foreword
2. Bacterial Resistance to Phages
2.1. Strategies to Minimize Bacterial Phage Resistance
2.2. Phages in Agriculture, Fisheries and Food
3. Phage Training
3.1. Phage Therapy and the Problem of Heterogeneity in Bacterial Populations
3.2. Phage Training?
3.3. Outcome of Phage Training
3.4. Relevance and Implementation of Phage Training in the Clinic
3.5. Regulatory Considerations Regarding Trained Phages
4. Prophages in Bacterial Production Strains
4.1. Relevance of Prophages to the Production of Therapeutic Phages
4.2. Detection of Prophages in Bacterial Genomes
4.3. Prophages in Bacterial Strains Used to Produce Therapeutic Phages
4.4. Prophages in Production Strains: What Does It Mean for the Licensing Pathway?
5. Concluding Remarks
5.1. Bacterial Phage Resistance
5.2. Phage Training
5.3. Prophages in Bacterial Production Strains
Acknowledgments
Conflicts of Interest
References
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Rohde, C.; Resch, G.; Pirnay, J.-P.; Blasdel, B.G.; Debarbieux, L.; Gelman, D.; Górski, A.; Hazan, R.; Huys, I.; Kakabadze, E.; et al. Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains. Viruses 2018, 10, 178. https://doi.org/10.3390/v10040178
Rohde C, Resch G, Pirnay J-P, Blasdel BG, Debarbieux L, Gelman D, Górski A, Hazan R, Huys I, Kakabadze E, et al. Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains. Viruses. 2018; 10(4):178. https://doi.org/10.3390/v10040178
Chicago/Turabian StyleRohde, Christine, Grégory Resch, Jean-Paul Pirnay, Bob G. Blasdel, Laurent Debarbieux, Daniel Gelman, Andrzej Górski, Ronen Hazan, Isabelle Huys, Elene Kakabadze, and et al. 2018. "Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strains" Viruses 10, no. 4: 178. https://doi.org/10.3390/v10040178