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Open AccessReview

Advances in HIV-1 Vaccine Development

1
Department of Microbiology and Immunology, University of Western Ontario, London, ON, N6A 5C1, Canada
2
Imperial College London, Department of Infectious Diseases, Division of Medicine, Norfolk Place, London, W2 1PG, UK
*
Author to whom correspondence should be addressed.
Viruses 2018, 10(4), 167; https://doi.org/10.3390/v10040167
Received: 18 March 2018 / Revised: 30 March 2018 / Accepted: 30 March 2018 / Published: 1 April 2018
(This article belongs to the Special Issue HIV Vaccines)
An efficacious HIV-1 vaccine is regarded as the best way to halt the ongoing HIV-1 epidemic. However, despite significant efforts to develop a safe and effective vaccine, the modestly protective RV144 trial remains the only efficacy trial to provide some level of protection against HIV-1 acquisition. This review will outline the history of HIV vaccine development, novel technologies being applied to HIV vaccinology and immunogen design, as well as the studies that are ongoing to advance our understanding of vaccine-induced immune correlates of protection. View Full-Text
Keywords: HIV-1; vaccine; antibodies; immunogen; neutralization HIV-1; vaccine; antibodies; immunogen; neutralization
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Gao, Y.; McKay, P.F.; Mann, J.F.S. Advances in HIV-1 Vaccine Development. Viruses 2018, 10, 167.

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