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Viruses 2018, 10(10), 521; https://doi.org/10.3390/v10100521

Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection

Section of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089-0641, USA
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Received: 12 September 2018 / Revised: 20 September 2018 / Accepted: 21 September 2018 / Published: 24 September 2018
(This article belongs to the Special Issue Cytokine Responses in Viral Infections)
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Abstract

Metabolism and immune responses are two fundamental biological processes that serve to protect hosts from viral infection. As obligate intracellular pathogens, viruses have evolved diverse strategies to activate metabolism, while inactivating immune responses to achieve maximal reproduction or persistence within their hosts. The two-way virus-host interaction with metabolism and immune responses choreograph cytokine production via reprogramming metabolism of infected cells/hosts. In return, cytokines can affect the metabolism of virus-infected and bystander cells to impede viral replication processes. This review aims to summarize our current understanding of the cross-talk between metabolic reprogramming and cytokine responses, and to highlight future potential research topics. Although the focus is placed on viral pathogens, relevant findings from other microbes are integrated to provide an overall picture, particularly when corresponding information on viral infection is lacking. View Full-Text
Keywords: metabolic reprogramming; innate immunity; cytokine response; immunometabolism metabolic reprogramming; innate immunity; cytokine response; immunometabolism
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhang, S.; Carriere, J.; Lin, X.; Xie, N.; Feng, P. Interplay between Cellular Metabolism and Cytokine Responses during Viral Infection. Viruses 2018, 10, 521.

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