Next Article in Journal
Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus
Previous Article in Journal
Mouse Gamma Herpesvirus MHV-68 Induces Severe Gastrointestinal (GI) Dilatation in Interferon Gamma Receptor-Deficient Mice (IFNγR−/−) That Is Blocked by Interleukin-10
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessArticle

Viruses.STRING: A Virus-Host Protein-Protein Interaction Database

Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, DK-2200 Copenhagen N, Danmark
Center for Non-Coding RNA in Technology and Health, University of Copenhagen, 1870 Frederiksberg C, Danmark
Swiss Institute of Bioinformatics, University of Zurich, 8006 Zurich, Switzerland
Author to whom correspondence should be addressed.
Viruses 2018, 10(10), 519;
Received: 3 September 2018 / Revised: 19 September 2018 / Accepted: 20 September 2018 / Published: 23 September 2018
PDF [1153 KB, uploaded 23 September 2018]


As viruses continue to pose risks to global health, having a better understanding of virus–host protein–protein interactions aids in the development of treatments and vaccines. Here, we introduce Viruses.STRING, a protein–protein interaction database specifically catering to virus–virus and virus–host interactions. This database combines evidence from experimental and text-mining channels to provide combined probabilities for interactions between viral and host proteins. The database contains 177,425 interactions between 239 viruses and 319 hosts. The database is publicly available at, and the interaction data can also be accessed through the latest version of the Cytoscape STRING app. View Full-Text
Keywords: protein–protein interactions; virus–host interactions; virus bioinformatics; PPI database protein–protein interactions; virus–host interactions; virus bioinformatics; PPI database

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Cook, H.V.; Doncheva, N.T.; Szklarczyk, D.; Von Mering, C.; Jensen, L.J. Viruses.STRING: A Virus-Host Protein-Protein Interaction Database. Viruses 2018, 10, 519.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top