Next Article in Journal
Interferon Response and Viral Evasion by Members of the Family Rhabdoviridae
Next Article in Special Issue
Defective Interfering RNAs: Foes of Viruses and Friends of Virologists
Previous Article in Journal
Maturation Pathways of Cross-Reactive HIV-1 Neutralizing Antibodies
Previous Article in Special Issue
Viroid Replication: Rolling-Circles, Enzymes and Ribozymes
Article Menu

Export Article

Open AccessReview

Hepatitis Delta Virus RNA Replication

Institute of Molecular Biology, Academia Sinica, Nankang, Taipei 115, Taiwan
Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
National Cheng-Kung University, Tainan 701, Taiwan
Author to whom correspondence should be addressed.
Viruses 2009, 1(3), 818-831;
Received: 28 September 2009 / Revised: 3 November 2009 / Accepted: 3 November 2009 / Published: 6 November 2009
(This article belongs to the Special Issue Subviral RNAs)
PDF [149 KB, uploaded 12 May 2015]


Hepatitis delta virus (HDV) is a distant relative of plant viroids in the animal world. Similar to plant viroids, HDV replicates its circular RNA genome using a double rolling-circle mechanism. Nevertheless, the production of hepatitis delta antigen (HDAg), which is indispensible for HDV replication, is a unique feature distinct from plant viroids, which do not encode any protein. Here the HDV RNA replication cycle is reviewed, with emphasis on the function of HDAg in modulating RNA replication and the nature of the enzyme involved. View Full-Text
Keywords: hepatitis delta virus; hepatitis delta antigen; RNA-dependent RNA synthesis; RNA polymerases; RNA replication hepatitis delta virus; hepatitis delta antigen; RNA-dependent RNA synthesis; RNA polymerases; RNA replication

Figure 1

This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

Share & Cite This Article

MDPI and ACS Style

Tseng, C.-H.; Lai, M.M.C. Hepatitis Delta Virus RNA Replication. Viruses 2009, 1, 818-831.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Viruses EISSN 1999-4915 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top