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Open AccessCommunication

Seroconversion to HCoV-NL63 in Rhesus Macaques

1
Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity (CINIMA), Academic Medical Centre (AMC), University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands
2
Department of Virology, Biomedical Primate Research Centre (BPRC), Lange Kleiweg 139, 2280 GH, Rijswijk, The Netherlands
*
Author to whom correspondence should be addressed.
Viruses 2009, 1(3), 647-656; https://doi.org/10.3390/v1030647
Received: 26 August 2009 / Revised: 28 October 2009 / Accepted: 30 October 2009 / Published: 30 October 2009
(This article belongs to the Special Issue Newly Identified Respiratory Viruses)
HCoV-NL63 is a recently identified respiratory virus. Its pathogenesis has not been fully unraveled because an animal model is currently lacking. Here we examined whether rhesus macaques encounter HCoV-NL63 infections during life, by examining the levels of antibodies to HCoV-NL63 in time. The animals were followed for 7 up till 19 years, and in three animals we observed a steep rise in antibodies during follow up, indicative of a natural infection with HCoV-NL63. View Full-Text
Keywords: HCoV-NL63; rhesus macaques HCoV-NL63; rhesus macaques
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Dijkman, R.; Mulder, H.L.; Rumping, L.; Kraaijvanger, I.; Deijs, M.; Jebbink, M.F.; Verschoor, E.J.; Van der Hoek, L. Seroconversion to HCoV-NL63 in Rhesus Macaques. Viruses 2009, 1, 647-656.

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