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A Closer Look at the NS1 of Influenza Virus

OIE/FAO and National Reference Laboratory for Avian influenza and Newcastle Disease, Istituto Zooprofilattico Sperimentale delle Venezie, Viale dell’ Università, 10, Legnaro (PD), 35020, Italy
Author to whom correspondence should be addressed.
Viruses 2009, 1(3), 1057-1072;
Received: 10 September 2009 / Revised: 13 November 2009 / Accepted: 25 November 2009 / Published: 26 November 2009
(This article belongs to the Special Issue Influenza: Pandemics and Vaccinations)
PDF [135 KB, uploaded 12 May 2015]


The Non-Structural 1 (NS1) protein is a multifactorial protein of type A influenza viruses that plays an important role in the virulence of the virus. A large amount of what we know about this protein has been obtained from studies using human influenza isolates and, consequently, the human NS1 protein. The current global interest in avian influenza, however, has highlighted a number of sequence and functional differences between the human and avian NS1. This review discusses these differences in addition to describing potential uses of NS1 in the management and control of avian influenza outbreaks. View Full-Text
Keywords: Non-Structural 1 protein; carboxy terminal; avian influenza; vaccination; DIVA Non-Structural 1 protein; carboxy terminal; avian influenza; vaccination; DIVA

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Dundon, W.G.; Capua, I. A Closer Look at the NS1 of Influenza Virus. Viruses 2009, 1, 1057-1072.

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