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Open AccessArticle

On the Determination of Magnesium Degradation Rates under Physiological Conditions

Division Metallic Biomaterials, Institute of Materials Research, Helmholtz-Zentrum Geesthacht, Max-Planck-Str. 1, Geesthacht 21502, Germany
Materials Technology, Hochschule Flensburg, Kanzleistraße 91–93, Flensburg 24943, Germany
Author to whom correspondence should be addressed.
Academic Editor: Raman Singh
Materials 2016, 9(8), 627;
Received: 15 June 2016 / Revised: 21 July 2016 / Accepted: 22 July 2016 / Published: 28 July 2016
(This article belongs to the Special Issue Degradable Biomaterials Based on Magnesium Alloys)
The current physiological in vitro tests of Mg degradation follow the procedure stated according to the ASTM standard. This standard, although useful in predicting the initial degradation behavior of an alloy, has its limitations in interpreting the same for longer periods of immersion in cell culture media. This is an important consequence as the alloy’s degradation is time dependent. Even if two different alloys show similar corrosion rates in a short term experiment, their degradation characteristics might differ with increased immersion times. Furthermore, studies concerning Mg corrosion extrapolate the corrosion rate from a single time point measurement to the order of a year (mm/y), which might not be appropriate because of time dependent degradation behavior. In this work, the above issues are addressed and a new methodology of performing long-term immersion tests in determining the degradation rates of Mg alloys was put forth. For this purpose, cast and extruded Mg-2Ag and powder pressed and sintered Mg-0.3Ca alloy systems were chosen. DMEM Glutamax +10% FBS (Fetal Bovine Serum) +1% Penicillin streptomycin was used as cell culture medium. The advantages of such a method in predicting the degradation rates in vivo deduced from in vitro experiments are discussed. View Full-Text
Keywords: in vitro; degradation; long-term immersion test; simulation in vitro; degradation; long-term immersion test; simulation
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Nidadavolu, E.P.S.; Feyerabend, F.; Ebel, T.; Willumeit-Römer, R.; Dahms, M. On the Determination of Magnesium Degradation Rates under Physiological Conditions. Materials 2016, 9, 627.

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