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Materials 2016, 9(4), 267;

Composite Hydrogels for Bone Regeneration

School of Engineering, University of Portsmouth, Anglesea Building, Anglesea Road, Portsmouth PO1 3DJ, UK
School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael’s Building, White Swan Road, Portsmouth PO1 2DT, UK
Author to whom correspondence should be addressed.
Academic Editor: Michael Nerlich
Received: 2 February 2016 / Revised: 14 March 2016 / Accepted: 29 March 2016 / Published: 2 April 2016
(This article belongs to the Special Issue Regenerative Materials)
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Over the past few decades, bone related disorders have constantly increased. Among all pathological conditions, osteoporosis is one of the most common and often leads to bone fractures. This is a massive burden and it affects an estimated 3 million people only in the UK. Furthermore, as the population ages, numbers are due to increase. In this context, novel biomaterials for bone fracture regeneration are constantly under development. Typically, these materials aim at favoring optimal bone integration in the scaffold, up to complete bone regeneration; this approach to regenerative medicine is also known as tissue engineering (TE). Hydrogels are among the most promising biomaterials in TE applications: they are very flexible materials that allow a number of different properties to be targeted for different applications, through appropriate chemical modifications. The present review will focus on the strategies that have been developed for formulating hydrogels with ideal properties for bone regeneration applications. In particular, aspects related to the improvement of hydrogels’ mechanical competence, controlled delivery of drugs and growth factors are treated in detail. It is hoped that this review can provide an exhaustive compendium of the main aspects in hydrogel related research and, therefore, stimulate future biomaterial development and applications. View Full-Text
Keywords: biomaterials; regenerative medicine; hydrogels; bone regeneration; tissue engineering; mechanical properties; growth factors; statins; bisphosphonates; hydroxyapatite biomaterials; regenerative medicine; hydrogels; bone regeneration; tissue engineering; mechanical properties; growth factors; statins; bisphosphonates; hydroxyapatite

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Tozzi, G.; De Mori, A.; Oliveira, A.; Roldo, M. Composite Hydrogels for Bone Regeneration. Materials 2016, 9, 267.

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