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Materials 2016, 9(3), 205;

Computational Study of the Effect of Cortical Porosity on Ultrasound Wave Propagation in Healthy and Osteoporotic Long Bones

Unit of Medical Technology and Intelligent Information Systems, Department of Materials Science and Engineering, University of Ioannina, GR 45110 Ioannina, Greece
Department of Mechanical Engineering and Aeronautics, University of Patras, GR 26500 Patras, Greece
Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Foundation for Research and Technology–Hellas, Institute of Molecular Biology and Biotechnology, Department of Biomedical Research, GR 45110 Ioannina, Greece
Author to whom correspondence should be addressed.
Academic Editor: Alkiviadis Paipetis
Received: 23 January 2016 / Revised: 23 February 2016 / Accepted: 8 March 2016 / Published: 17 March 2016
(This article belongs to the Special Issue Acoustic Waves in Advanced Materials)
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Computational studies on the evaluation of bone status in cases of pathologies have gained significant interest in recent years. This work presents a parametric and systematic numerical study on ultrasound propagation in cortical bone models to investigate the effect of changes in cortical porosity and the occurrence of large basic multicellular units, simply called non-refilled resorption lacunae (RL), on the velocity of the first arriving signal (FAS). Two-dimensional geometries of cortical bone are established for various microstructural models mimicking normal and pathological tissue states. Emphasis is given on the detection of RL formation which may provoke the thinning of the cortical cortex and the increase of porosity at a later stage of the disease. The central excitation frequencies 0.5 and 1 MHz are examined. The proposed configuration consists of one point source and multiple successive receivers in order to calculate the FAS velocity in small propagation paths (local velocity) and derive a variation profile along the cortical surface. It was shown that: (a) the local FAS velocity can capture porosity changes including the occurrence of RL with different number, size and depth of formation; and (b) the excitation frequency 0.5 MHz is more sensitive for the assessment of cortical microstructure. View Full-Text
Keywords: ultrasound; bone modeling; osteoporosis; cortical porosity; basic multicellular units ultrasound; bone modeling; osteoporosis; cortical porosity; basic multicellular units

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T. Potsika, V.; N. Grivas, K.; Gortsas, T.; Iori, G.; C. Protopappas, V.; Raum, K.; Polyzos, D.; I. Fotiadis, D. Computational Study of the Effect of Cortical Porosity on Ultrasound Wave Propagation in Healthy and Osteoporotic Long Bones. Materials 2016, 9, 205.

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