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10.3390/ma9030198
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Article

Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers

by
Hsi-Chin Wu
1,*,
Tzu-Wei Wang
2,
Jui-Sheng Sun
3,*,
Yi-Hsuan Lee
1,2,
Meng-Han Shen
1,
Zong-Ruei Tsai
1,
Chih-Yu Chen
4 and
Horng-Chaung Hsu
5
1
Department of Materials Engineering, Tatung University, Taipei 10461, Taiwan
2
Department of Materials Science and Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan
3
Department of Orthopedic Surgery, National Taiwan University Hospital, Taipei 10041, Taiwan
4
Department of Biomedical Engineering, National Yang-Ming University, Taipei 11221, Taiwan
5
Department of Orthopedics, China Medical University Hospital, Taichung 40447, Taiwan
*
Authors to whom correspondence should be addressed.
Materials 2016, 9(3), 198; https://doi.org/10.3390/ma9030198
Submission received: 29 January 2016 / Revised: 2 March 2016 / Accepted: 10 March 2016 / Published: 15 March 2016
(This article belongs to the Section Biomaterials)
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Abstract

Various kinds of three-dimensional (3D) scaffolds have been designed to mimic the biological spontaneous bone formation characteristics by providing a suitable microenvironment for osteogenesis. In view of this, a natural bone-liked composite scaffold, which was combined with inorganic (hydroxyapatite, Hap) and organic (type I collagen, Col) phases, has been developed through a self-assembly process. This 3D porous scaffold consisting of a c-axis of Hap nanocrystals (nHap) aligning along Col fibrils arrangement is similar to natural bone architecture. A significant increase in mechanical strength and elastic modulus of nHap/Col scaffold is achieved through biomimetic mineralization process when compared with simple mixture of collagen and hydroxyapatite method. It is suggested that the self-organization of Hap and Col produced in vivo could also be achieved in vitro. The oriented nHap/Col composite not only possesses bone-like microstructure and adequate mechanical properties but also enhances the regeneration and reorganization abilities of bone tissue. These results demonstrated that biomimetic nHap/Col can be successfully reconstructed as a bone graft substitute in bone tissue engineering.
Keywords: nanocomposite; hydroxyapatite nanocrystal; biomimetic scaffold nanocomposite; hydroxyapatite nanocrystal; biomimetic scaffold
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MDPI and ACS Style

Wu, H.-C.; Wang, T.-W.; Sun, J.-S.; Lee, Y.-H.; Shen, M.-H.; Tsai, Z.-R.; Chen, C.-Y.; Hsu, H.-C. Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials 2016, 9, 198. https://doi.org/10.3390/ma9030198

AMA Style

Wu H-C, Wang T-W, Sun J-S, Lee Y-H, Shen M-H, Tsai Z-R, Chen C-Y, Hsu H-C. Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials. 2016; 9(3):198. https://doi.org/10.3390/ma9030198

Chicago/Turabian Style

Wu, Hsi-Chin, Tzu-Wei Wang, Jui-Sheng Sun, Yi-Hsuan Lee, Meng-Han Shen, Zong-Ruei Tsai, Chih-Yu Chen, and Horng-Chaung Hsu. 2016. "Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers" Materials 9, no. 3: 198. https://doi.org/10.3390/ma9030198

APA Style

Wu, H.-C., Wang, T.-W., Sun, J.-S., Lee, Y.-H., Shen, M.-H., Tsai, Z.-R., Chen, C.-Y., & Hsu, H.-C. (2016). Development and Characterization of a Bioinspired Bone Matrix with Aligned Nanocrystalline Hydroxyapatite on Collagen Nanofibers. Materials, 9(3), 198. https://doi.org/10.3390/ma9030198

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