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Mineralized Collagen: Rationale, Current Status, and Clinical Applications

School of Materials Science and Engineering, Tsinghua University, Haidian District, Beijing 100084, China
Beijing Allgens Medical Science and Technology Co., Ltd., No.1 Disheng East Road, Yizhuang Economic and Technological Development Zone, Beijing 100176, China
The 401 Hospital of Chinese People's Liberation Army, No. 22 Minjiang Road, Qingdao 266071, China
The General Hospital of People's Liberation Army, No. 28 Fuxing Road, Beijing 100853, China
Author to whom correspondence should be addressed.
Academic Editor: Franz E. Weber
Materials 2015, 8(8), 4733-4750;
Received: 16 May 2015 / Revised: 29 June 2015 / Accepted: 13 July 2015 / Published: 24 July 2015
(This article belongs to the Special Issue Novel Bone Substitute Materials)
PDF [2470 KB, uploaded 24 July 2015]


This paper presents a review of the rationale for the in vitro mineralization process, preparation methods, and clinical applications of mineralized collagen. The rationale for natural mineralized collagen and the related mineralization process has been investigated for decades. Based on the understanding of natural mineralized collagen and its formation process, many attempts have been made to prepare biomimetic materials that resemble natural mineralized collagen in both composition and structure. To date, a number of bone substitute materials have been developed based on the principles of mineralized collagen, and some of them have been commercialized and approved by regulatory agencies. The clinical outcomes of mineralized collagen are of significance to advance the evaluation and improvement of related medical device products. Some representative clinical cases have been reported, and there are more clinical applications and long-term follow-ups that currently being performed by many research groups. View Full-Text
Keywords: mineralized collagen; collagen; hydroxyapatite; biomineralization; self-assembly; medical device product; clinical application mineralized collagen; collagen; hydroxyapatite; biomineralization; self-assembly; medical device product; clinical application

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Qiu, Z.-Y.; Cui, Y.; Tao, C.-S.; Zhang, Z.-Q.; Tang, P.-F.; Mao, K.-Y.; Wang, X.-M.; Cui, F.-Z. Mineralized Collagen: Rationale, Current Status, and Clinical Applications. Materials 2015, 8, 4733-4750.

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