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Materials 2015, 8(6), 2873-2886;

Methods for Biomimetic Mineralisation of Human Enamel: A Systematic Review

Faculty of Dentistry, the University of Hong Kong, Hong Kong, China
Stomatological Hospital and College, Anhui Medical University, Key Lab. of Oral Diseases Research of Anhui Province, Hefei 230032, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Greta Patzke
Received: 23 April 2015 / Revised: 11 May 2015 / Accepted: 18 May 2015 / Published: 26 May 2015
Full-Text   |   PDF [216 KB, uploaded 26 May 2015]   |  


Biomimetic mineralisation is an alternative restorative methodology that imitates the natural process of mineralisation. We aimed to systematically review the laboratory methods on the biomimetic mineralisation of demineralised enamel. A search in the PubMed, ScienceDirect, and ISI Web of Science databases was performed. Clinical trials, reviews, non-English articles, animal teeth, non-tooth substrates, and irrelevant studies were excluded. After screening the titles and abstracts of initially searched articles, 20 papers remained for full-text analysis. Eight articles were identified from the references of the remaining papers. A total of 28 studies were included in this systematic review. We found that protein or protein analogues were used to mimic the function of natural protein in 23 studies. Bioactive components inspired by mussel, an agarose hydrogel model, a glycerine-enriched gelatine technique, and ethylenediaminetetraacetic acid, were also used for biomimetic mineralisation of enamel. These laboratory studies reported success in the biomimetic mineralisation of enamel. Potential further research on the biomimetic mineralisation of enamel was discussed. View Full-Text
Keywords: biomimetic; mineralisation; enamel; proteins biomimetic; mineralisation; enamel; proteins

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Cao, C.Y.; Mei, M.L.; Li, Q.-L.; Lo, E.C.M.; Chu, C.H. Methods for Biomimetic Mineralisation of Human Enamel: A Systematic Review. Materials 2015, 8, 2873-2886.

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