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Materials 2015, 8(5), 2297-2310;

Process Optimisation to Control the Physico-Chemical Characteristics of Biomimetic Nanoscale Hydroxyapatites Prepared Using Wet Chemical Precipitation

School of Clinical Dentistry, University of Sheffield, 19 Claremont Crescent, Sheffield S10 2TA, UK
Author to whom correspondence should be addressed.
Academic Editor: Andrew J. Ruys
Received: 25 February 2015 / Revised: 15 April 2015 / Accepted: 20 April 2015 / Published: 29 April 2015
(This article belongs to the Special Issue Bioceramics)
Full-Text   |   PDF [934 KB, uploaded 29 April 2015]   |  


Hydroxyapatite nanoscale particles (nHA) were prepared by wet chemical precipitation using four different synthesis methods. Differences in physico-chemical properties including morphology, particle-size, and crystallinity were investigated following alteration of critical processing parameters. The nanoparticles were also studied using X-ray diffraction (XRD), Fourier Transform infrared spectroscopy in attenuated total reflectance mode (FTIR-ATR), and transmission electron microscopy (TEM) with energy dispersive X-ray (EDS) spectrometry. The results showed that the particles obtained were composed of nHA, with different morphologies and aspect ratios (1.5 to 4) and degrees of crystallinity (40% to 70% following calcination) depending on the different process parameters of the synthesis method used, such as temperature, ripening time and pH. This study demonstrated that relatively small adjustments to processing conditions of different wet chemical preparation methods significantly affect the morphological and chemical characteristics of nHA. For the predicable preparation of biomimetic nHA for specific applications, the selection of both production method and careful control of processing conditions are paramount. View Full-Text
Keywords: bioceramics; hydroxyapatite; nanoparticles; processing; wet-precipitation bioceramics; hydroxyapatite; nanoparticles; processing; wet-precipitation

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Gentile, P.; Wilcock, C.J.; Miller, C.A.; Moorehead, R.; Hatton, P.V. Process Optimisation to Control the Physico-Chemical Characteristics of Biomimetic Nanoscale Hydroxyapatites Prepared Using Wet Chemical Precipitation. Materials 2015, 8, 2297-2310.

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