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Article

Medium-Term Function of a 3D Printed TCP/HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation

1
Division of Fixed Prosthodontics and Biomaterials, University of Geneva, University Clinics of Dental Medicine, 19, rue Barthélemy-Menn, Geneva 1205, Switzerland
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Department of Maxillofacial and Oral Surgery, Division of Oral and Maxillofacial Pathology (HUG), University Clinics of Dental Medicine, 19, rue Barthélemy-Menn, Geneva 1205, Switzerland
*
Author to whom correspondence should be addressed.
Academic Editor: Naozumi Teramoto
Materials 2015, 8(5), 2174-2190; https://doi.org/10.3390/ma8052174
Received: 2 March 2015 / Revised: 30 March 2015 / Accepted: 20 April 2015 / Published: 28 April 2015
(This article belongs to the Special Issue Bioceramics)
Introduction: A 3D-printed construct made of orthogonally layered strands of tricalcium phosphate (TCP) and hydroxyapatite has recently become available. The material provides excellent osteoconductivity. We simulated a medium-term experiment in a sheep calvarial model by priming the blocks with BMP-2. Vertical bone growth/maturation and material resorption were evaluated. Materials and methods: Titanium hemispherical caps were filled with either bare- or BMP-2 primed constructs and placed onto the calvaria of adult sheep (n = 8). Histomorphometry was performed after 8 and 16 weeks. Results: After 8 weeks, relative to bare constructs, BMP-2 stimulation led to a two-fold increase in bone volume (Bare: 22% ± 2.1%; BMP-2 primed: 50% ± 3%) and a 3-fold decrease in substitute volume (Bare: 47% ± 5%; BMP-2 primed: 18% ± 2%). These rates were still observed at 16 weeks. The new bone grew and matured to a haversian-like structure while the substitute material resorbed via cell- and chemical-mediation. Conclusion: By priming the 3D construct with BMP-2, bone metabolism was physiologically accelerated, that is, enhancing vertical bone growth and maturation as well as material bioresorption. The scaffolding function of the block was maintained, leaving time for the bone to grow and mature to a haversian-like structure. In parallel, the material resorbed via cell-mediated and chemical processes. These promising results must be confirmed in clinical tests. View Full-Text
Keywords: bone substitute block; 3D-printing; BMP-2; animal experiments; guided tissue regeneration; bone regeneration bone substitute block; 3D-printing; BMP-2; animal experiments; guided tissue regeneration; bone regeneration
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MDPI and ACS Style

Moussa, M.; Carrel, J.-P.; Scherrer, S.; Cattani-Lorente, M.; Wiskott, A.; Durual, S. Medium-Term Function of a 3D Printed TCP/HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation. Materials 2015, 8, 2174-2190. https://doi.org/10.3390/ma8052174

AMA Style

Moussa M, Carrel J-P, Scherrer S, Cattani-Lorente M, Wiskott A, Durual S. Medium-Term Function of a 3D Printed TCP/HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation. Materials. 2015; 8(5):2174-2190. https://doi.org/10.3390/ma8052174

Chicago/Turabian Style

Moussa, Mira, Jean-Pierre Carrel, Susanne Scherrer, Maria Cattani-Lorente, Anselm Wiskott, and Stéphane Durual. 2015. "Medium-Term Function of a 3D Printed TCP/HA Structure as a New Osteoconductive Scaffold for Vertical Bone Augmentation: A Simulation by BMP-2 Activation" Materials 8, no. 5: 2174-2190. https://doi.org/10.3390/ma8052174

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