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Active Nanomaterials to Meet the Challenge of Dental Pulp Regeneration

French National Institute of Health and Medical Research (INSERM), Osteoarticular and Dental, Regenerative Nanomedicine, UMR 1109, Faculté de Médecine de l’Université de Strasbourg and FMTS, 11 rue Humann, Strasbourg 67000, France
Faculté de Chirurgie Dentaire de l’Université de Strasbourg, 8 rue Ste Elisabeth, Strasbourg 67000, France
Universitaires de Strasbourg (HUS), Université de Strasbourg, Strasbourg 67000, France
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Marco Salerno
Materials 2015, 8(11), 7461-7471;
Received: 28 August 2015 / Accepted: 19 October 2015 / Published: 5 November 2015
(This article belongs to the Special Issue Therapeutics Delivery Systems for Regenerative Nanomedicine)
The vitality of the pulp is fundamental to the functional life of the tooth. For this aim, active and living biomaterials are required to avoid the current drastic treatment, which is the removal of all the cellular and molecular content regardless of its regenerative potential. The regeneration of the pulp tissue is the dream of many generations of dental surgeons and will revolutionize clinical practices. Recently, the potential of the regenerative medicine field suggests that it would be possible to achieve such complex regeneration. Indeed, three crucial steps are needed: the control of infection and inflammation and the regeneration of lost pulp tissues. For regenerative medicine, in particular for dental pulp regeneration, the use of nano-structured biomaterials becomes decisive. Nano-designed materials allow the concentration of many different functions in a small volume, the increase in the quality of targeting, as well as the control of cost and delivery of active molecules. Nanomaterials based on extracellular mimetic nanostructure and functionalized with multi-active therapeutics appear essential to reverse infection and inflammation and concomitantly to orchestrate pulp cell colonization and differentiation. This novel generation of nanomaterials seems very promising to meet the challenge of the complex dental pulp regeneration. View Full-Text
Keywords: regenerative nanomedicine; dental pulp; endodontic regeneration; electrospun nanofibrous membrane regenerative nanomedicine; dental pulp; endodontic regeneration; electrospun nanofibrous membrane
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Keller, L.; Offner, D.; Schwinté, P.; Morand, D.; Wagner, Q.; Gros, C.; Bornert, F.; Bahi, S.; Musset, A.-M.; Benkirane-Jessel, N.; Fioretti, F. Active Nanomaterials to Meet the Challenge of Dental Pulp Regeneration. Materials 2015, 8, 7461-7471.

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