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Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces

Department of Dental Materials and Biomaterial Research, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
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Materials 2014, 7(6), 4473-4492; https://doi.org/10.3390/ma7064473
Received: 1 April 2014 / Revised: 20 May 2014 / Accepted: 5 June 2014 / Published: 12 June 2014
(This article belongs to the Special Issue Ceramics for Healthcare 2013)
High-strength ceramics as materials for medical implants have a long, research-intensive history. Yet, especially on applications where the ceramic components are in direct contact with the surrounding tissue, an unresolved issue is its inherent property of biological inertness. To combat this, several strategies have been investigated over the last couple of years. One promising approach investigates the technique of Self-Assembled Monolayers (SAM) and subsequent chemical functionalization to create a biologically active tissue-facing surface layer. Implementation of this would have a beneficial impact on several fields in modern implant medicine such as hip and knee arthroplasty, dental applications and related fields. This review aims to give a summarizing overview of the latest advances in this recently emerging field, along with thorough introductions of the underlying mechanism of SAMs and surface cell attachment mechanics on the cell side. View Full-Text
Keywords: alumina; bioactivation; self-assembled monolayers; tissue-integration; high-strength ceramics alumina; bioactivation; self-assembled monolayers; tissue-integration; high-strength ceramics
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Böke, F.; Schickle, K.; Fischer, H. Biological Activation of Inert Ceramics: Recent Advances Using Tailored Self-Assembled Monolayers on Implant Ceramic Surfaces. Materials 2014, 7, 4473-4492.

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