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Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy

1
Center for Soft Condensed Matter Physics and Interdisciplinary Research, Soochow University, Suzhou 215006, Jiangsu, China
2
National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, Nanjing 210093, Jiangsu, China
3
Institute for Frontier Materials, Deakin University, Waurn Ponds, Vic 3216, Australia
*
Authors to whom correspondence should be addressed.
Materials 2014, 7(5), 3481-3493; https://doi.org/10.3390/ma7053481
Received: 6 March 2014 / Revised: 26 March 2014 / Accepted: 21 April 2014 / Published: 30 April 2014
Phthalocyanine (Pc) is a type of promising sensitizer molecules for photodynamic therapy (PDT), but its hydrophobicity substantially prevents its applications. In this study, we efficiently encapsulate Pc into poly(N-isopropylacrylamide) (pNIPAM) microgel particles, without or with lipid decoration (i.e., [email protected] or [email protected]/lipid), to improve its water solubility and prevent aggregation in aqueous medium. The incorporation of lipid molecules significantly enhances the Pc loading efficiency of pNIPAM. These [email protected] and [email protected]/lipid composite microspheres show thermo-triggered release of Pc and/or lipid due to the phase transition of pNIPAM. Furthermore, in the in vitro experiments, these composite particles work as drug carriers for the hydrophobic Pc to be internalized into HeLa cells. After internalization, the particles show efficient fluorescent imaging and PDT effect. Our work demonstrates promising candidates in promoting the use of hydrophobic drugs including photosensitizers in tumor therapies. View Full-Text
Keywords: phthalocyanine; phospholipid; composite microsphere; controlled release; photodynamic therapy phthalocyanine; phospholipid; composite microsphere; controlled release; photodynamic therapy
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Liu, J.; Li, J.; Zhang, Z.; Weng, Y.; Chen, G.; Yuan, B.; Yang, K.; Ma, Y. Encapsulation of Hydrophobic Phthalocyanine with Poly(N-isopropylacrylamide)/Lipid Composite Microspheres for Thermo-Responsive Release and Photodynamic Therapy. Materials 2014, 7, 3481-3493.

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