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Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity

Department of Biological Sciences and Technology, National University of Tainan, 33, Sec. 2, Shu-Lin St., Tainan 700, Taiwan, China
Materials 2012, 5(9), 1661-1685;
Received: 8 August 2012 / Revised: 30 August 2012 / Accepted: 5 September 2012 / Published: 17 September 2012
(This article belongs to the Special Issue Advances in Cosmetics)
Melanogenesis is a biosynthetic pathway for the formation of the pigment melanin in human skin. A key enzyme, tyrosinase, catalyzes the first and only rate-limiting steps in melanogenesis, and the down-regulation of enzyme activity is the most reported method for the inhibition of melanogenesis. Because of the cosmetically important issue of hyperpigmentation, there is a big demand for melanogenesis inhibitors. This encourages researchers to seek potent melanogenesis inhibitors for cosmetic uses. This article reviews melanogenesis inhibitors that have been recently discovered from natural sources. The reaction mechanisms of the inhibitors on tyrosinase activity are also discussed. View Full-Text
Keywords: inhibitors; melanogenesis; tyrosinase inhibitors; melanogenesis; tyrosinase
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Chang, T.-S. Natural Melanogenesis Inhibitors Acting Through the Down-Regulation of Tyrosinase Activity. Materials 2012, 5, 1661-1685.

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